Association of Extreme Nocturnal Dipping With Cardiovascular Events Strongly Depends on Age.
Age Factors
Blood Pressure
/ physiology
Blood Pressure Monitoring, Ambulatory
/ methods
Cardiovascular Diseases
/ diagnosis
Circadian Rhythm
/ physiology
Female
Humans
Hypertension
/ diagnosis
Hypotension
/ diagnosis
Longitudinal Studies
Male
Middle Aged
Outcome Assessment, Health Care
Prognosis
Risk Assessment
Risk Factors
association
blood pressure
prospective studies
risk factors
sex
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
24
12
2019
medline:
22
10
2020
entrez:
24
12
2019
Statut:
ppublish
Résumé
Whether extreme dipping is associated with cardiovascular events (CVE) is unclear. The present study was conducted to test the hypothesis that the prognostic role of extreme dipping varies as a function of age. The analysis was performed in 10 868 participants (53% men) aged 53±15 (mean±SD) years enrolled in 8 prospective studies. Using the ambulatory systolic blood pressure nocturnal decline, we identified 4 groups: dippers (>10%-20%), nondippers (>0%-10%), reverse dippers (≤0%), and extreme dippers (>20%). The association between dipping category and CVE was estimated as a function of age using Cox models adjusted for sex, average 24-hour systolic blood pressure, and traditional risk factors. During a median follow-up of 5.7 years, there were a total of 829 CVE (168 fatal). For extreme dippers, no increase in risk of CVE was observed among the participants <70 years (hazard ratio, 0.99 [95% CI, 0.73-1.34];
Identifiants
pubmed: 31865788
doi: 10.1161/HYPERTENSIONAHA.119.14085
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM