Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes

Animals Cell Line, Tumor Enzyme-Linked Immunosorbent Assay Everolimus / therapeutic use Female Fluorescent Antibody Technique Humans Mice, Inbred C57BL Mice, Nude Microscopy, Electron, Transmission Nanoparticles / chemistry Neoplasms / drug therapy RNA, Messenger / genetics TOR Serine-Threonine Kinases / genetics Tumor Suppressor Protein p53 / genetics

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
18 12 2019
Historique:
received: 02 12 2018
revised: 23 08 2019
accepted: 20 11 2019
entrez: 20 12 2019
pubmed: 20 12 2019
medline: 15 9 2020
Statut: ppublish

Résumé

Loss of function in tumor suppressor genes is commonly associated with the onset/progression of cancer and treatment resistance. The

Identifiants

DOI: 10.1126/scitranslmed.aaw1565 PMID: 31852795 PMC: PMC7024563
pubmed: 31852795
pii: 11/523/eaaw1565
doi: 10.1126/scitranslmed.aaw1565
pmc: PMC7024563
mid: NIHMS1555938
pii:
doi:

Substances chimiques

RNA, Messenger 0
Tumor Suppressor Protein p53 0
Everolimus 9HW64Q8G6G
TOR Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : P30 CA006516
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS072030
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA200900
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA174650
Pays : United States

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Na Kong (N)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China.
ORCID: 0000-0002-3823-8335

Wei Tao (W)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. wtao@bwh.harvard.edu tianxie@hznu.edu.cn ofarokhzad@bwh.harvard.edu jshi@bwh.harvard.edu.
ORCID: 0000-0002-4277-3728

Xiang Ling (X)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Junqing Wang (J)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0002-9091-9891

Yuling Xiao (Y)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Sanjun Shi (S)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Xiaoyuan Ji (X)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Cancer Pharmacology, Holistic Integrative Pharmacy Institutes, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

Aram Shajii (A)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Silvia Tian Gan (ST)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.

Na Yoon Kim (NY)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
ORCID: 0000-0001-6169-7452

Dan G Duda (DG)

Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
ORCID: 0000-0001-7065-8797

Tian Xie (T)

Department of Cancer Pharmacology, Holistic Integrative Pharmacy Institutes, College of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China. wtao@bwh.harvard.edu tianxie@hznu.edu.cn ofarokhzad@bwh.harvard.edu jshi@bwh.harvard.edu.
ORCID: 0000-0003-4368-760X

Omid C Farokhzad (OC)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. wtao@bwh.harvard.edu tianxie@hznu.edu.cn ofarokhzad@bwh.harvard.edu jshi@bwh.harvard.edu.
King Abdulaziz University, Jeddah 21589, Saudi Arabia.
ORCID: 0000-0003-2009-270X

Jinjun Shi (J)

Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. wtao@bwh.harvard.edu tianxie@hznu.edu.cn ofarokhzad@bwh.harvard.edu jshi@bwh.harvard.edu.
ORCID: 0000-0001-9200-5068

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Techniques d'immunoadsorption › Test ELISA › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Composés chimiques organiques › Lactones › Sirolimus › Évérolimus › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Techniques d'investigation › Techniques immunologiques › Technique d'immunofluorescence › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Techniques d'investigation › Microscopie électronique › Microscopie électronique à transmission › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Tumeurs › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Synthetic mRNA nanoparticle-mediated...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › Protéine p53 suppresseur de tumeur › Synthetic mRNA nanoparticle-mediated...