Emerging treatment options for patients with p53-pathway-deficient CLL.
17p deletion
CLL
TP53 mutation
ibrutinib
idelalisib
venetoclax
Journal
Therapeutic advances in hematology
ISSN: 2040-6207
Titre abrégé: Ther Adv Hematol
Pays: England
ID NLM: 101549589
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
08
2019
accepted:
06
11
2019
entrez:
17
12
2019
pubmed:
17
12
2019
medline:
17
12
2019
Statut:
epublish
Résumé
Over the past 40 years, p53 has been the most widely studied protein in cancer biology. Originally thought to be an oncogene due to its stabilization in many cancers, it is now considered to be one of the most critical tumor suppressors in a cell's ability to combat neoplastic transformation. Due to its critical roles in apoptosis, cell-cycle arrest, and senescence,
Identifiants
pubmed: 31839919
doi: 10.1177/2040620719891356
pii: 10.1177_2040620719891356
pmc: PMC6896129
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
2040620719891356Subventions
Organisme : NCI NIH HHS
ID : R01 CA207204
Pays : United States
Informations de copyright
© The Author(s), 2019.
Déclaration de conflit d'intérêts
Conflict of interest statement: The author(s) declare that there is no conflict of interest.
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