Capillary blood tests may overestimate ketosis: triangulation between three different measures of β-hydroxybutyrate.
capillary
ketosis
methods comparison
venous
β-hydroxybutyrate
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
pubmed:
11
12
2019
medline:
6
5
2020
entrez:
11
12
2019
Statut:
ppublish
Résumé
The ketone body β-hydroxybutyrate (BHB), assessed by a point-of-care meter in venous whole blood (BHBv), was used as the main outcome in a study on nutritional ketosis in healthy older adults. Two other BHB measures were also used in the study for validation and exploratory purposes, and here we report findings on correlation and agreement between those three methods. Ketosis in the range of 0-1.5 mmol/L was induced in 15 healthy volunteers by intake of medium-chain fatty acids after a 12-h fast. BHBv was assessed at 12 time points for 4 h. The same point-of-care meter was also used to test capillary blood (BHBc) at three time points, and a laboratory test determined total ketones (TK) in plasma (BHBp + acetoacetate) at four time points. A total of 180 cases included simultaneous data on BHBv, BHBc, BHBp, and TK. TK correlated with BHBp (Pearson's
Identifiants
pubmed: 31821040
doi: 10.1152/ajpendo.00454.2019
doi:
Substances chimiques
Fatty Acids
0
Ketones
0
3-Hydroxybutyric Acid
TZP1275679
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
E184-E188Commentaires et corrections
Type : ErratumIn