Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards.

Afghan Campaign 2001- Air Pollutants / adverse effects Biomarkers / blood Dioxins / adverse effects Female Furans / adverse effects Humans Incineration / statistics & numerical data Inhalation Exposure / adverse effects Iraq War, 2003-2011 Machine Learning Male Mass Spectrometry MicroRNAs / blood Military Personnel / statistics & numerical data Polycyclic Aromatic Hydrocarbons / adverse effects United States Waste Disposal Facilities / statistics & numerical data

Journal

Journal of occupational and environmental medicine
ISSN: 1536-5948
Titre abrégé: J Occup Environ Med
Pays: United States
ID NLM: 9504688

Informations de publication

Date de publication:
12 2019
Historique:
entrez: 5 12 2019
pubmed: 5 12 2019
medline: 17 9 2020
Statut: ppublish

Résumé

The potential health risks of deployment to sites with open burn pits remain poorly understood, in part, because personal exposure monitoring was not performed. Here, we investigated whether postdeployment serum samples contain biomarkers associated with exposure to burn pits. A total of 237 biomarkers were measured in 800 serum samples from deployed and never-deployed subjects. We used a regression model and a supervised vector machine to identify serum biomarkers with significant associations with exposures and deployment. We identified 101 serum biomarkers associated with polycyclic aromatic hydrocarbons, dioxins or furans, and 54 biomarkers associated with deployment. Twenty-six of these biomarkers were shared in common by the exposure and deployment groups. We identify a potential signature of exposure to open burn pits, and provide a framework for using postexposure sera to identify exposures when contemporaneous monitoring was inadequate.

Identifiants

DOI: 10.1097/JOM.0000000000001715 PMID: 31800450 PMC: PMC6901100
pubmed: 31800450
doi: 10.1097/JOM.0000000000001715
pii: 00043764-201912001-00006
pmc: PMC6901100
mid: NIHMS1539504
doi:

Substances chimiques

Air Pollutants 0
Biomarkers 0
Dioxins 0
Furans 0
MicroRNAs 0
Polycyclic Aromatic Hydrocarbons 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

S45-S54

Subventions

Organisme : NIEHS NIH HHS
ID : P30 ES001247
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL066988
Pays : United States

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Auteurs

Thomas H Thatcher (TH)

Department of Medicine, University of Rochester Medical Center, Rochester, New York (Dr Thatcher, Dr Sime, Dr Phipps, and Dr Utell); Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York (Dr Woeller, Dr Sime, Dr Phipps, and Dr Utell); Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York (Dr Thakar, Dr Khan, Dr Sime, and Dr Phipps); Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, New York (Dr Thakar and Dr Khan); Department of Public Health Sciences, University of Rochester Medical Center, Rochester, New York (Dr Hopke); Center for Air Resources Engineering and Science, Clarkson University, Potsdam, New York (Dr Hopke); Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, Georgia (Dr Smith, Dr Uppal, Dr Walker, Dr Go, and Dr Jones); Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York (Dr Walker); Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland (Dr Krahl and Dr Mallon); Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia (Dr Thatcher and Dr Sime).

Collynn F Woeller (CF)

Juilee Thakar (J)

Atif Khan (A)

Philip K Hopke (PK)

Matthew Ryan Smith (MR)

Karan Uppal (K)

Douglas I Walker (DI)

Young-Mi Go (YM)

Dean P Jones (DP)

Pamela L Krahl (PL)

Timothy M Mallon (TM)

Patricia J Sime (PJ)

Richard P Phipps (RP)

Mark J Utell (MJ)

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Classifications MeSH

Recherchemedicale.com › Sciences humaines › Histoire › Histoire moderne 1601- › Histoire du 21ème siècle › Guerre d'Afghanistan 2001- › Analysis of Postdeployment Serum Samples...
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