Brain morphological and functional features in cognitive subgroups of schizophrenia.
Adult
Cerebral Cortex
/ diagnostic imaging
Cognitive Dysfunction
/ diagnostic imaging
Connectome
Corpus Striatum
/ diagnostic imaging
Female
Gray Matter
/ diagnostic imaging
Hippocampus
/ diagnostic imaging
Humans
Intelligence
/ physiology
Magnetic Resonance Imaging
Male
Middle Aged
Schizophrenia
/ complications
Young Adult
brain functional connectivity
brain morphology
cognitive decline
cognitive subgroup
schizophrenia
Journal
Psychiatry and clinical neurosciences
ISSN: 1440-1819
Titre abrégé: Psychiatry Clin Neurosci
Pays: Australia
ID NLM: 9513551
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
03
06
2019
revised:
30
10
2019
accepted:
26
11
2019
pubmed:
4
12
2019
medline:
15
12
2020
entrez:
4
12
2019
Statut:
ppublish
Résumé
Previous studies have reported different brain morphologies in different cognitive subgroups of patients with schizophrenia. We aimed to examine the brain structures and functional connectivity in these cognitive subgroups of schizophrenia. We compared brain structures among healthy controls and cognitively deteriorated and preserved subgroups of patients with schizophrenia according to the decline in IQ. Connectivity analyses between subcortical regions and other brain areas were performed using resting-state functional magnetic resonance imaging among the groups. Whole brain and total cortical gray matter, right fusiform gyrus, left pars orbitalis gyrus, right pars triangularis, left superior temporal gyrus and left insula volumes, and bilateral cortical thickness were decreased in the deteriorated group compared to the control and preserved groups. Both schizophrenia subgroups had increased left lateral ventricle, right putamen and left pallidum, and decreased bilateral hippocampus, left precentral gyrus, right rostral middle frontal gyrus, and bilateral superior frontal gyrus volumes compared with controls. Hyperconnectivity between the thalamus and a broad range of brain regions was observed in the deteriorated group compared to connectivity in the control group, and this hyperconnectivity was less evident in the preserved group. We also found hyperconnectivity between the accumbens and the superior and middle frontal gyri in the preserved group compared with connectivity in the deteriorated group. These findings provide evidence of prominent structural and functional brain abnormalities in deteriorated patients with schizophrenia, suggesting that cognitive subgroups in schizophrenia might be useful biotypes to elucidate brain pathophysiology for new diagnostic and treatment strategies.
Identifiants
pubmed: 31793131
doi: 10.1111/pcn.12963
pmc: PMC7065166
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-203Subventions
Organisme : International Research Center for Neurointelligence (WPI-IRCN)
Organisme : Grants-in-Aid for Scientific Research
Organisme : Health and Labor Sciences Research Grants
Organisme : Brain/MINDS
ID : JP19dm0207069
Organisme : Brain/MINDS
ID : JP18dm0207006
Informations de copyright
© 2019 The Authors. Psychiatry and Clinical Neurosciences published by John Wiley & Sons Australia, Ltd on behalf of Japanese Society of Psychiatry and Neurology.
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