B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments.

Adoptive Transfer Animals Antigen Presentation B-Lymphocytes / cytology Endosomes / metabolism Female Histocompatibility Antigens Class II / immunology Humans Lysosomes / metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Protein Transport Receptors, Antigen, B-Cell / genetics
Adaptive immune system Antigen processing B cell receptor B cells BCR Endosomes MHCII Peptide loading Vesicle traffic

Journal

Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457

Informations de publication

Date de publication:
20 12 2019
Historique:
received: 30 06 2019
accepted: 20 11 2019
pubmed: 30 11 2019
medline: 22 9 2020
entrez: 30 11 2019
Statut: epublish

Résumé

In order to mount high-affinity antibody responses, B cells internalise specific antigens and process them into peptides loaded onto MHCII for presentation to T helper cells (T

Identifiants

DOI: 10.1242/jcs.235192 PMID: 31780582
pubmed: 31780582
pii: jcs.235192
doi: 10.1242/jcs.235192
pii:
doi:

Substances chimiques

Histocompatibility Antigens Class II 0
Receptors, Antigen, B-Cell 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2019. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Auteurs

Sara Hernández-Pérez (S)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.
Turku Bioscience, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
ORCID: 0000-0002-0227-1045

Marika Vainio (M)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.
Turku Bioscience, University of Turku and Åbo Akademi University, 20520 Turku, Finland.

Elina Kuokkanen (E)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.

Vid Šuštar (V)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.

Petar Petrov (P)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.
Turku Bioscience, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
ORCID: 0000-0001-5551-8032

Sofia Forstén (S)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.
Turku Bioscience, University of Turku and Åbo Akademi University, 20520 Turku, Finland.

Vilma Paavola (V)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.

Johanna Rajala (J)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.

Luqman O Awoniyi (LO)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.
Turku Bioscience, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
ORCID: 0000-0001-7809-3268

Alexey V Sarapulov (AV)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland.
Turku Bioscience, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
ORCID: 0000-0001-6445-7438

Helena Vihinen (H)

Institute of Biotechnology, Electron Microscopy Unit, 00014 University of Helsinki, Finland.
ORCID: 0000-0003-3862-9237

Eija Jokitalo (E)

Institute of Biotechnology, Electron Microscopy Unit, 00014 University of Helsinki, Finland.
ORCID: 0000-0002-4159-6934

Andreas Bruckbauer (A)

Facility for Imaging by Light Microscopy (FILM), National Heart and Lung Institute, Imperial College London, London SW7 2AZ, UK.
ORCID: 0000-0003-1419-9674

Pieta K Mattila (PK)

Institute of Biomedicine, and MediCity Research Laboratories, University of Turku, 20014 Turku, Finland pieta.mattila@utu.fi.
Turku Bioscience, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
ORCID: 0000-0003-2805-0686

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Classifications MeSH

Recherchemedicale.com › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › B cells rapidly target antigen and...
Recherchemedicale.com › Eucaryotes › Animaux › B cells rapidly target antigen and...
Recherchemedicale.com › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Présentation d'antigène › B cells rapidly target antigen and...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › B cells rapidly target antigen and...
Recherchemedicale.com › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Endosomes › B cells rapidly target antigen and...
Recherchemedicale.com › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe II › B cells rapidly target antigen and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › B cells rapidly target antigen and...
Recherchemedicale.com › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › B cells rapidly target antigen and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › B cells rapidly target antigen and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › B cells rapidly target antigen and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › B cells rapidly target antigen and...
Recherchemedicale.com › Métabolisme › Transport biologique › Transport des protéines › B cells rapidly target antigen and...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs pour l'antigène des lymphocytes B › B cells rapidly target antigen and...