Trillions and Trillions: Herpes Simplex Virus-1 Hepatitis in an Immunocompetent Adult.

HSV hepatitis HSV-1 hepatitis herpes simplex virus host response viral evolution

Journal

Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 02 10 2019
accepted: 23 10 2019
entrez: 29 11 2019
pubmed: 30 11 2019
medline: 30 11 2019
Statut: epublish

Résumé

We describe a case of acute liver failure and myopericarditis due to herpes simplex virus-1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.

Identifiants

DOI: 10.1093/ofid/ofz465 PMID: 31777756 PMC: PMC6868424
pubmed: 31777756
doi: 10.1093/ofid/ofz465
pii: ofz465
pmc: PMC6868424
doi:

Types de publication

Journal Article

Langues

eng

Pagination

ofz465

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007044
Pays : United States

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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Auteurs

Kevin Ikuta (K)

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

Pavitra Roychoudhury (P)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Hong Xie (H)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Christopher L Mcclurkan (CL)

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

Magdalena Walkiewicz (M)

Immunopathogenesis Section, National Institute of Allergy and Infectious Disease, Bethesda, Maryland, USA.

Negar Makhsous (N)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Meei-Li Huang (ML)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Yodit Beru (Y)

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Mariam Alam (M)

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Amanda Shepherd (A)

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Eric D Lamotte (ED)

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Kevin Patel (K)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Amy Morris (A)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Başak Ҫoruh (B)

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.

Lei Yu (L)

Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Renuka Bhattacharya (R)

Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Rex Cheng (R)

Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Roland B Walter (RB)

Clinical Research Division, Fred Hutchinson Cancer Research Center Seattle, Washington, USA.

Ajit P Limaye (AP)

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

Christina M Lockwood (CM)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Steven M Holland (SM)

Immunopathogenesis Section, National Institute of Allergy and Infectious Disease, Bethesda, Maryland, USA.

Robert M Rakita (RM)

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.

David M Koelle (DM)

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Department of Global Health, University of Washington, Seattle, Washington, USA.
Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Benaroya Research Institute, Seattle, Washington, USA.

Alexander L Greninger (AL)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.
Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Classifications MeSH