The Plasma Factor XIII Heterotetrameric Complex Structure: Unexpected Unequal Pairing within a Symmetric Complex.

HADDOCK flexible docking atomic force microscopy coagulation factor XIII complex cross-linking mass spectrometry isothermal titration calorimetry molecular dynamics simulation threaded modeling

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
21 11 2019
Historique:
received: 25 10 2019
revised: 15 11 2019
accepted: 19 11 2019
entrez: 27 11 2019
pubmed: 27 11 2019
medline: 28 8 2020
Statut: epublish

Résumé

Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with two catalytic A subunits and two carrier-protective B subunits in a heterotetramer (FXIII-A

Identifiants

pubmed: 31766577
pii: biom9120765
doi: 10.3390/biom9120765
pmc: PMC6995596
pii:
doi:

Substances chimiques

Protein Subunits 0
Factor XIII 9013-56-3
Thrombin EC 3.4.21.5
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL126974
Pays : United States

Déclaration de conflit d'intérêts

Authors declare no conflict of interest.

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Auteurs

Sneha Singh (S)

Institute of Experimental Hematology and Transfusion medicine, University Hospital of Bonn, Sigmund-Freud Street 25, 53127 Bonn, Germany.

Alexis Nazabal (A)

CovalX, Schützengasse 2, CH-8001 Zürich, Switzerland.

Senthilvelrajan Kaniyappan (S)

German Center for Neurodegenerative Diseases (DZNE), Sigmund-Freud-Str. 27, 53127 Bonn, Germany.

Jean-Luc Pellequer (JL)

Univ. Grenoble Alpes, CEA, CNRS, IBS, F-38000 Grenoble, France.

Alisa S Wolberg (AS)

Department of Pathology and Laboratory Medicine and UNC Blood Research Center, University of North Carolina at Chapel Hill, 8018A Mary Ellen Jones Building, Chapel Hill, NC 27599-7035, USA.

Diana Imhof (D)

Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany.

Johannes Oldenburg (J)

Institute of Experimental Hematology and Transfusion medicine, University Hospital of Bonn, Sigmund-Freud Street 25, 53127 Bonn, Germany.

Arijit Biswas (A)

Institute of Experimental Hematology and Transfusion medicine, University Hospital of Bonn, Sigmund-Freud Street 25, 53127 Bonn, Germany.

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