Obesity Impairs Mobility and Adult Hippocampal Neurogenesis.
Leptin
Morris water maze
hippocampus
mice
neuronal plasticity
obesity
Journal
Journal of experimental neuroscience
ISSN: 1179-0695
Titre abrégé: J Exp Neurosci
Pays: United States
ID NLM: 101517658
Informations de publication
Date de publication:
2019
2019
Historique:
received:
15
08
2019
accepted:
24
09
2019
entrez:
26
11
2019
pubmed:
26
11
2019
medline:
26
11
2019
Statut:
epublish
Résumé
Currently, it is controversially discussed whether a relationship between obesity and cognition exists. We here analyzed a mouse model of obesity (leptin-deficient mice) to study the effects of obesity on the morphology of the hippocampus (a brain structure involved in mechanisms related to learning and memory) and on behavior. Mice aged 4 to 6 months were analyzed. At this age, the obese mice have nearly double the body weight as controls, but display smaller brains (brain volume is about 10% smaller) as control animals of the same age. Adult hippocampal neurogenesis, a process that is linked to learning and memory, might be disturbed in the obese mice and contribute to the smaller brain volume. Adult hippocampal neurogenesis was examined using specific markers for cell proliferation (phosphohistone H3), neuronal differentiation (doublecortin), and apoptosis (caspase 3). The number of phosphohistone H3 and doublecortin-positive cells was markedly reduced in leptin-deficient mice, but not the number of apoptotic cells, indicating that adult hippocampal neurogenesis on the level of cell proliferation was affected. In addition, dendritic spine densities of pyramidal neurons in the hippocampal area CA1 were analyzed using Golgi impregnation. However, no significant change in dendritic spine densities was noted in the obese mice. Moreover, the performance of the mice was analyzed in the open field as well as in the Morris water maze. In the open field test, obese mice showed reduced locomotor activity, but in the Morris water maze they showed similar performance compared with control animals.
Identifiants
pubmed: 31765441
doi: 10.1177/1179069519883580
pii: 10.1177_1179069519883580
pmc: PMC6852358
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1179069519883580Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Neurosci Lett. 2010 Oct 4;482(3):235-9
pubmed: 20670674
Diabetologia. 2013 Mar;56(3):627-34
pubmed: 23224631
Obes Rev. 2012 Jan;13(1):43-56
pubmed: 21902800
J Neural Transm (Vienna). 2017 Nov;124(11):1431-1454
pubmed: 28766040
Biochem Biophys Res Commun. 1999 Mar 24;256(3):600-2
pubmed: 10080944
Biol Psychiatry. 2006 May 1;59(9):793-800
pubmed: 16325153
Int J Environ Res Public Health. 2015 Jul 17;12(7):8281-94
pubmed: 26193295
Hippocampus. 2008;18(11):1085-8
pubmed: 18651634
Cell Tissue Res. 2010 Dec;342(3):317-23
pubmed: 21080001
Nat Protoc. 2006;1(2):848-58
pubmed: 17406317
Behav Brain Res. 1983 Feb;7(2):133-53
pubmed: 6830648
J Neurosci Methods. 1984 May;11(1):47-60
pubmed: 6471907
Proc Natl Acad Sci U S A. 2019 May 28;116(22):10988-10993
pubmed: 31085646
Neuroreport. 2010 Dec 29;21(18):1140-5
pubmed: 20926971
Cell Tissue Res. 2011 Jul;345(1):1-19
pubmed: 21647561
Arch Clin Neuropsychol. 2008 Jul;23(4):467-74
pubmed: 18448310
Curr Protoc Pharmacol. 2012 Sep;Chapter 5:Unit5.61
pubmed: 22948848
Diabetologia. 2015 Sep;58(9):2133-43
pubmed: 26058503
Endocrinology. 1999 Jun;140(6):2755-62
pubmed: 10342866
Nat Genet. 2000 May;25(1):102-4
pubmed: 10802666
Physiol Behav. 2010 Oct 5;101(3):381-8
pubmed: 20637218
Nat Neurosci. 2008 Mar;11(3):309-17
pubmed: 18278039
Obes Res Clin Pract. 2015 Mar-Apr;9(2):93-113
pubmed: 25890426
J Biosoc Sci. 2012 Mar;44(2):165-79
pubmed: 22004667
J Clin Endocrinol Metab. 2004 Jun;89(6):2583-9
pubmed: 15181027
Int J Obes (Lond). 2006 Sep;30(9):1449-60
pubmed: 16534518
J Sports Med Phys Fitness. 2007 Sep;47(3):344-50
pubmed: 17641603
Neurology. 2006 Oct 10;67(7):1208-14
pubmed: 17030754
J Biol Chem. 2008 Jun 27;283(26):18238-47
pubmed: 18367451
Am J Med Genet B Neuropsychiatr Genet. 2014 Apr;165B(3):245-53
pubmed: 24619555
Neuroscience. 2002;113(3):607-15
pubmed: 12150780
Epidemiol Rev. 2013;35:22-32
pubmed: 23258415
Dement Geriatr Cogn Disord. 2010;29(6):543-52
pubmed: 20606436
Eur J Neurol. 2006 Dec;13(12):1385-8
pubmed: 17116226
Front Neurosci. 2018 Mar 16;12:155
pubmed: 29615850
Hippocampus. 2009 Oct;19(10):951-61
pubmed: 19280661
Neuroepidemiology. 2010;34(4):222-9
pubmed: 20299802
Compr Psychiatry. 2007 Jan-Feb;48(1):57-61
pubmed: 17145283
BMJ. 2001 Mar 24;322(7288):716-20
pubmed: 11264213
J Sport Exerc Psychol. 2007 Apr;29(2):239-52
pubmed: 17568069
Brain Struct Funct. 2018 Jun;223(5):2287-2302
pubmed: 29473106