Changes in the elimination and resurgence of alcohol-maintained behavior in rats and the effects of naltrexone.
Journal
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
ISSN: 1939-1501
Titre abrégé: Psychol Addict Behav
Pays: United States
ID NLM: 8802734
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
pubmed:
22
11
2019
medline:
4
9
2020
entrez:
22
11
2019
Statut:
ppublish
Résumé
Resurgence may be a mechanism of relapse in alcohol use disorder patients upon discharge from treatment as part of an abuse-treatment-relapse cycle. Adjunctive pharmacotherapies may be a means to facilitate behavioral treatments and block resurgence. Experiments were conducted using a model of alcohol self-administration to assess the repeatability of the elimination and resurgence of alcohol-maintained behavior and the effects of naltrexone. Experiments had three phases. In Phase 1, behavior was maintained by oral alcohol under a fixed-ratio schedule. In Phase 2, behavior was extinguished via condensed milk delivery under a differential-reinforcement-of-other-behavior (DRO) schedule. In Phase 3, the DRO schedule was eliminated. In Experiment 1, this 3-phase cycle was replicated 4 times. Across replications, response rates and dose of alcohol consumed did not differ in Phase 1, alcohol-maintained behavior was eliminated more rapidly in Phase 2, and the resurgence effect was generally stable in Phase 3. In Experiment 2, naltrexone was administered in Phase 2, Phase 3, or both Phases 2 and 3, to separate groups of rats. Naltrexone facilitated the elimination of alcohol-maintained behavior in Phase 2 and, the resurgence of alcohol-maintained behavior was reduced only for those rats that received naltrexone in both phases. Together, these experiments demonstrate that the resurgence of alcohol-maintained behavior is replicable within-subjects and, further, resurgence of alcohol-maintained behavior may be a useful model to evaluate pharmacological interventions to facilitate behavioral treatments and reduce the likelihood of relapse. Results with naltrexone support the use of medication-assisted therapy approaches to reduce relapse risk in patients. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
Identifiants
pubmed: 31750701
pii: 2019-68475-001
doi: 10.1037/adb0000525
pmc: PMC7007344
mid: NIHMS1053453
doi:
Substances chimiques
Alcohol Deterrents
0
Ethanol
3K9958V90M
Naltrexone
5S6W795CQM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10-22Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121334
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA016179
Pays : United States
Références
J Exp Anal Behav. 2019 Jul;112(1):1-9
pubmed: 30883795
Behav Brain Res. 2015 Feb 15;279:47-51
pubmed: 25446761
Clin Psychol Rev. 2006 Mar;26(2):149-61
pubmed: 16364524
Neuropsychopharmacology. 2011 Apr;36(5):1015-20
pubmed: 21228769
Alcohol Res Health. 2011;33(4):380-8
pubmed: 23580022
J Exp Anal Behav. 2009 Nov;92(3):327-43
pubmed: 20514165
Psychopharmacology (Berl). 2019 Jun;236(6):1797-1806
pubmed: 30637435
Psychol Health Med. 2015;20(8):916-26
pubmed: 25531935
Behav Processes. 2017 Aug;141(Pt 1):100-127
pubmed: 27794452
J Exp Psychol. 1953 Nov;46(5):349-52
pubmed: 13109138
Behav Processes. 2012 May;90(1):101-10
pubmed: 22425783
Behav Pharmacol. 2006 Jun;17(4):369-74
pubmed: 16914956
Neuropharmacology. 2013 Sep;72:139-47
pubmed: 23643750
J Exp Anal Behav. 1982 Jan;37(1):149-55
pubmed: 7057126
Curr Drug Abuse Rev. 2012 Mar;5(1):52-63
pubmed: 22280332
J Exp Psychol Anim Behav Process. 2006 Jul;32(3):322-8
pubmed: 16834499
Behav Processes. 2017 May;138:29-33
pubmed: 28216120
Behav Brain Res. 2014 Sep 1;271:122-8
pubmed: 24914462
J Exp Anal Behav. 2011 May;95(3):271-87
pubmed: 21547067
J Exp Anal Behav. 2014 Sep;102(2):231-40
pubmed: 25125267
Behav Brain Res. 2016 Jun 1;306:48-51
pubmed: 26988268
J Exp Anal Behav. 1976 Sep;26(2):181-90
pubmed: 16811939
Behav Processes. 2017 Aug;141(Pt 1):85-91
pubmed: 28487201
Neuropsychopharmacology. 1999 Sep;21(3):435-44
pubmed: 10457541
Psychopharmacology (Berl). 2009 Jun;204(2):335-48
pubmed: 19153715
J Appl Behav Anal. 2009 Spring;42(1):145-60
pubmed: 19721735
J Pharmacol Exp Ther. 1995 Jul;274(1):17-28
pubmed: 7616395
J Exp Anal Behav. 2018 Nov;110(3):545-552
pubmed: 30324728
Addiction. 2006 Feb;101(2):192-203
pubmed: 16445548
Lancet. 2018 Jan 27;391(10118):309-318
pubmed: 29150198
JAMA Psychiatry. 2015 May;72(5):430-7
pubmed: 25760804
Behav Res Ther. 1973 Feb;11(1):91-104
pubmed: 4781962
Learn Behav. 2013 Dec;41(4):414-24
pubmed: 23982985
J Exp Anal Behav. 2016 Nov;106(3):225-241
pubmed: 27870107
Prev Med. 2012 Nov;55 Suppl:S46-53
pubmed: 22668883
Addiction. 2016 Apr;111(4):695-705
pubmed: 26599131
Behav Processes. 2007 Jun;75(2):115-28
pubmed: 17395402
Curr Addict Rep. 2014 Mar;1(1):41-52
pubmed: 24914414
Neuropsychopharmacology. 2002 Sep;27(3):391-9
pubmed: 12225696
Prev Med. 2016 Nov;92:36-46
pubmed: 27514250
J Exp Anal Behav. 2016 May;105(3):375-92
pubmed: 27193242
Behav Anal. 2012 Spring;35(1):89-100
pubmed: 22942538
J Exp Anal Behav. 1969 Jan;12(1):73-80
pubmed: 16811341
J Clin Psychiatry. 2015 Feb;76(2):e207-13
pubmed: 25742208
J Consult Clin Psychol. 2000 Apr;68(2):250-7
pubmed: 10780125
Behav Processes. 2015 Feb;111:37-41
pubmed: 25464338
J Exp Anal Behav. 2003 Sep;80(2):217-33
pubmed: 14674730
J Neurosci. 2002 Sep 15;22(18):7856-61
pubmed: 12223538
Behav Res Methods. 2005 Aug;37(3):379-84
pubmed: 16405133
J Exp Anal Behav. 2019 Jan;111(1):28-47
pubmed: 30656711
Alcohol Clin Exp Res. 2004 Apr;28(4):558-65
pubmed: 15100606
J Exp Psychol. 1951 Oct;42(4):273-81
pubmed: 14888834
Psychol Methods. 2003 Dec;8(4):434-47
pubmed: 14664681
Alcohol. 2008 Nov;42(7):553-63
pubmed: 18774673
JAMA. 2014 May 14;311(18):1889-900
pubmed: 24825644
Behav Processes. 2000 Dec 7;52(2-3):117-129
pubmed: 11164680
Behav Processes. 2015 Jun;115:70-3
pubmed: 25712040
Alcohol. 2001 Jul;24(3):205-9
pubmed: 11557306
JAMA. 2000 Oct 4;284(13):1689-95
pubmed: 11015800
Behav Processes. 2014 May;104:13-9
pubmed: 24576702
Addict Behav. 2011 Jun;36(6):584-9
pubmed: 21377275
Learn Motiv. 2013 Feb 1;44(1):60-71
pubmed: 23515657
J Exp Anal Behav. 2012 May;97(3):281-304
pubmed: 22693359
J Subst Abuse Treat. 2005;28 Suppl 1:S63-72
pubmed: 15797640
Behav Brain Res. 2018 Apr 2;341:54-62
pubmed: 29258811
Alcohol Alcohol. 2011 Sep-Oct;46(5):561-9
pubmed: 21622676