Methylation of drug resistance-related genes in chemotherapy-sensitive Epstein-Barr virus-associated gastric cancer.
ATP Binding Cassette Transporter, Subfamily G, Member 2
/ genetics
Antineoplastic Agents
/ pharmacology
Cell Line
Cisplatin
/ pharmacology
Cytoskeletal Proteins
/ genetics
DNA Methylation
/ drug effects
DNA, Neoplasm
/ drug effects
Drug Combinations
Drug Resistance, Neoplasm
/ drug effects
Fluorouracil
/ pharmacology
Frizzled Receptors
/ genetics
Gene Silencing
/ drug effects
Herpesvirus 4, Human
/ drug effects
Humans
Male
Middle Aged
Neoplasm Proteins
/ genetics
Oligonucleotide Array Sequence Analysis
Oxonic Acid
/ pharmacology
Promoter Regions, Genetic
/ drug effects
Proto-Oncogene Proteins c-bcl-2
/ genetics
Stomach Neoplasms
/ drug therapy
Tegafur
/ pharmacology
Tumor Protein p73
/ genetics
DNA methylation
EBV
Epstein-Barr virus-associated gastric cancer
chemotherapy
drug susceptibility
gastric cancer
Journal
FEBS open bio
ISSN: 2211-5463
Titre abrégé: FEBS Open Bio
Pays: England
ID NLM: 101580716
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
09
06
2019
accepted:
15
11
2019
pubmed:
19
11
2019
medline:
5
1
2021
entrez:
19
11
2019
Statut:
ppublish
Résumé
Epstein-Barr virus (EBV)-associated gastric cancer (GC) is associated with a high degree of DNA methylation. However, the association between chemotherapy susceptibility and tumor DNA methylation in advanced diseases remains unclear. The comprehensive DNA methylation status of GC cells obtained from an advanced EBV-associated GC (EBVGC) case, in which complete response to S-1 plus cisplatin chemotherapy was achieved, was analyzed using a DNA methylation microarray. We compared DNA methylation of GC cells with public data and identified genes with higher methylation in EBVGC cell lines than in normal gastric cells, and genes in which methylation was increased by EBV. Of these genes, ABCG2, AHNAK2, BCL2, FZD1, and TP73 are associated with published evidence for resistance to 5-fluorouracil and cisplatin. Silencing of these genes may be associated with hypersensitivity to chemotherapy.
Identifiants
pubmed: 31736281
doi: 10.1002/2211-5463.12765
pmc: PMC6943226
doi:
Substances chimiques
ABCG2 protein, human
0
AHNAK2 protein, human
0
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
Antineoplastic Agents
0
BCL2 protein, human
0
Cytoskeletal Proteins
0
DNA, Neoplasm
0
Drug Combinations
0
FZD1 protein, human
0
Frizzled Receptors
0
Neoplasm Proteins
0
Proto-Oncogene Proteins c-bcl-2
0
TP73 protein, human
0
Tumor Protein p73
0
S 1 (combination)
150863-82-4
Tegafur
1548R74NSZ
Oxonic Acid
5VT6420TIG
Cisplatin
Q20Q21Q62J
Fluorouracil
U3P01618RT
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
147-157Informations de copyright
© 2019 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
Références
Clin Cancer Res. 2006 May 15;12(10):2995-3002
pubmed: 16707594
Sci Rep. 2017 Aug 11;7(1):7924
pubmed: 28801683
J Clin Oncol. 2004 Feb 15;22(4):664-70
pubmed: 14966089
Epigenomics. 2016 Mar;8(3):389-99
pubmed: 26673039
Arch Pharm Res. 2011 Apr;34(4):635-43
pubmed: 21544729
Nat Genet. 2000 May;25(1):25-9
pubmed: 10802651
Genome Biol. 2016 Oct 7;17(1):208
pubmed: 27717381
Chin J Cancer. 2014 Jun;33(6):285-94
pubmed: 24589211
Cancer Res. 2002 Mar 15;62(6):1920-6
pubmed: 11912175
Genome Res. 2006 Mar;16(3):383-93
pubmed: 16449502
Biomed Pharmacother. 2016 Dec;84:123-129
pubmed: 27643554
Sci Rep. 2017 Mar 03;7:43109
pubmed: 28256505
Nucleic Acids Res. 2017 Jan 4;45(D1):D331-D338
pubmed: 27899567
Int J Cancer. 2015 Mar 1;136(5):E359-86
pubmed: 25220842
Nucleic Acids Res. 2002 Jan 1;30(1):207-10
pubmed: 11752295
Bioinformatics. 2009 Jan 15;25(2):288-9
pubmed: 19033274
Mol Cells. 2011 Aug;32(2):173-9
pubmed: 21626300
Oncotarget. 2015 Oct 13;6(31):31018-29
pubmed: 26427042
Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):272-84
pubmed: 14734480
Nature. 2014 Sep 11;513(7517):202-9
pubmed: 25079317
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Oligonucleotides. 2006 Fall;16(3):263-74
pubmed: 16978089
J Pathol. 2017 Aug;242(4):391-399
pubmed: 28418084
Viruses. 2012 Dec;4(12):3420-39
pubmed: 23342366
Lancet Oncol. 2008 Mar;9(3):215-21
pubmed: 18282805
J Clin Oncol. 2006 Nov 1;24(31):4991-7
pubmed: 17075117