Multiscale effects of spaceflight on murine tendon and bone.
Composition
Enthesis
Mechanics
Spaceflight
Structure
Journal
Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
13
09
2019
revised:
07
11
2019
accepted:
09
11
2019
pubmed:
16
11
2019
medline:
22
6
2021
entrez:
16
11
2019
Statut:
ppublish
Résumé
Despite a wealth of data on the effects of spaceflight on tendons and bones, little is known about its effects on the interfacial tissue between these two structures, the enthesis. Mice were sent to space on three separate missions: STS-131, STS-135, and Bion-M1 to determine how spaceflight affects the composition, structure, mechanics, and gene expression of the humerus-supraspinatus and calcaneus-Achilles entheses. At the nanoscale, spaceflight resulted in decreased carbonate levels in the bone, likely due to increased remodeling, as suggested by increased expression of genes related to osteoclastogenesis (CatK, Tnfsf11) and mature osteoblasts (Col1, Osc). Tendons showed a shift in collagen fibril size towards smaller diameters that may have resulted from increased expression of genes related to collagen degradation (Mmp3, Mmp13). These nanoscale changes did not result in micro- and milliscale changes to the structure and mechanics of the enthesis. There were no changes in bone volume, trabecular structure, failure load, or stiffness with spaceflight. This lack of tissue-level change may be anatomy based, as extremities may be less sensitive to spaceflight than central locations such as vertebrae, yet results highlight that the tendon enthesis may be robust against negative effects of spaceflight.
Identifiants
pubmed: 31730829
pii: S8756-3282(19)30446-6
doi: 10.1016/j.bone.2019.115152
pmc: PMC7138367
mid: NIHMS1544144
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
115152Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR074992
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR047867
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR055580
Pays : United States
Organisme : NIBIB NIH HHS
ID : U01 EB016422
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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