A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas.
Cabergoline
Dopamine agonist
Malformation
Miscarriage
Pregnancy
Prolactinoma
Journal
Pituitary
ISSN: 1573-7403
Titre abrégé: Pituitary
Pays: United States
ID NLM: 9814578
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
pubmed:
16
11
2019
medline:
5
1
2021
entrez:
16
11
2019
Statut:
ppublish
Résumé
To evaluate the maternal-fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, RESULTS: We included 194 women with a mean age of 31 (17-45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.
Identifiants
pubmed: 31728906
doi: 10.1007/s11102-019-01008-z
pii: 10.1007/s11102-019-01008-z
doi:
Substances chimiques
Dopamine Agonists
0
Cabergoline
LL60K9J05T
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
120-128Références
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