Injury-Triggered Blueing Reactions of Psilocybe "Magic" Mushrooms.
enzymes
laccase
natural products
phosphatase
psilocybin
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
20 01 2020
20 01 2020
Historique:
received:
13
08
2019
pubmed:
15
11
2019
medline:
14
1
2021
entrez:
15
11
2019
Statut:
ppublish
Résumé
Upon injury, psychotropic psilocybin-producing mushrooms instantly develop an intense blue color, the chemical basis and mode of formation of which has remained elusive. We report two enzymes from Psilocybe cubensis that carry out a two-step cascade to prepare psilocybin for oxidative oligomerization that leads to blue products. The phosphatase PsiP removes the 4-O-phosphate group to yield psilocin, while PsiL oxidizes its 4-hydroxy group. The PsiL reaction was monitored by in situ
Identifiants
pubmed: 31725937
doi: 10.1002/anie.201910175
pmc: PMC7004109
doi:
Substances chimiques
Biological Products
0
Hallucinogens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1450-1454Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : HO2515/7-1
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB 1127
Pays : International
Organisme : Carl-Zeiss-Stiftung
Pays : International
Organisme : Leibniz-Gemeinschaft
ID : Int.Leibniz Research School MibIntact
Pays : International
Informations de copyright
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
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