Brief Report: Adipogenic Expression of Brown Fat Genes in HIV and HIV-Related Parameters.
Adipose Tissue, Brown
/ metabolism
Amino Acid Transport Systems, Neutral
/ genetics
Anti-HIV Agents
/ therapeutic use
CD4 Lymphocyte Count
DNA-Binding Proteins
/ genetics
Gene Expression
HIV Infections
/ drug therapy
HIV Integrase Inhibitors
/ therapeutic use
HIV Protease Inhibitors
/ therapeutic use
Humans
Male
Membrane Proteins
/ genetics
Middle Aged
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ genetics
RNA, Messenger
/ metabolism
Receptors, Purinergic P2X5
/ genetics
Reverse Transcriptase Inhibitors
/ therapeutic use
Subcutaneous Fat, Abdominal
/ metabolism
Symporters
/ genetics
Transcription Factors
/ genetics
Tumor Necrosis Factor Receptor Superfamily, Member 9
/ genetics
Uncoupling Protein 1
/ genetics
Viral Load
Journal
Journal of acquired immune deficiency syndromes (1999)
ISSN: 1944-7884
Titre abrégé: J Acquir Immune Defic Syndr
Pays: United States
ID NLM: 100892005
Informations de publication
Date de publication:
15 12 2019
15 12 2019
Historique:
entrez:
13
11
2019
pubmed:
13
11
2019
medline:
3
6
2020
Statut:
ppublish
Résumé
Persons with HIV are at increased risk for adipose dysfunction, which could mediate metabolic complications such as cardiovascular disease, fatty liver disease, and diabetes. We have previously reported reduced browning and beiging capacity of the subcutaneous adipose depot in HIV. We sought to evaluate how HIV-related parameters are related to the expression of brown and beige fat genes in the abdominal subcutaneous adipose tissue. Eighteen persons with HIV underwent punch biopsy of abdominal subcutaneous fat to determine mRNA expression of adipose-related genes using quantitative reverse transcriptase-polymerase chain reaction. Duration of antiretroviral therapy use, particularly related to protease inhibitor use, was significantly related to reduced expression of multiple brown and beige fat genes (including UCP1, PGC1α, PRDM16 and others, all P ≤ 0.04) in the abdominal subcutaneous fat. In addition, duration of HIV and CD4 T-cell count were significantly correlated with reduced expression of multiple brown and beige fat genes in the abdominal subcutaneous fat (PGC1α, P2XR5, TMEM26, CD137, all P ≤ 0.05 for duration of HIV; and PGC1α, ZIC1, PRDM16, PAT2, P2RX5, TMEM26, CD137, all P ≤ 0.04). In contrast, HIV viral load did not correlate with any brown or beige fat genes. Key HIV-related parameters reflective of nonacute infection (increased duration of HIV and duration of antiretroviral therapy use) or relatively reduced immunologic function (lower CD4 count) were linked to reduced expression of brown and beige fat gene in the abdominal subcutaneous adipose depot. NCT01098045.
Identifiants
pubmed: 31714428
doi: 10.1097/QAI.0000000000002180
pii: 00126334-201912150-00010
pmc: PMC6857717
mid: NIHMS1539097
doi:
Substances chimiques
Amino Acid Transport Systems, Neutral
0
Anti-HIV Agents
0
DNA-Binding Proteins
0
HIV Integrase Inhibitors
0
HIV Protease Inhibitors
0
Membrane Proteins
0
P2RX5 protein, human
0
PPARGC1A protein, human
0
PRDM16 protein, human
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
RNA, Messenger
0
Receptors, Purinergic P2X5
0
Reverse Transcriptase Inhibitors
0
SLC36A2 protein, human
0
Symporters
0
TMEM26 protein, human
0
TNFRSF9 protein, human
0
Transcription Factors
0
Tumor Necrosis Factor Receptor Superfamily, Member 9
0
UCP1 protein, human
0
Uncoupling Protein 1
0
ZIC1 protein, human
0
Banques de données
ClinicalTrials.gov
['NCT01098045']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
491-495Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002541
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001066
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR025758
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL136262
Pays : United States
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