Acute hypotension attenuates brachial flow-mediated dilation in young healthy men.
Blood pressure
Endothelial function
Flow-mediated dilation
Hypotension
Sympathetic activity
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
19
07
2019
accepted:
01
11
2019
pubmed:
9
11
2019
medline:
2
10
2020
entrez:
9
11
2019
Statut:
ppublish
Résumé
This study aimed to test our hypothesis that acute hypotension attenuates brachial flow-mediated dilation (FMD) as an index of endothelial function in healthy humans. Twelve healthy men (21.8 ± 1.6 years, body mass index; 22.2 ± 1.6 kg/m Mean arterial pressure during reactive hyperaemia showed a marked decrease in the hypotension trial (- 23.7 ± 6.0 mmHg), but not in the control and SR reduction trials. SR area under the curve was attenuated in the SR reduction trial (P < 0.001), but not in the control and hypotension trials (P = 0.316). Consequently, FMD was attenuated in the hypotension and SR reduction trials compared with that in the control trial (P = 0.003 and P = 0.043, respectively), and was attenuated to a greater extent in the hypotension trial compared with the SR reduction trial (P = 0.006; control, 6.9 ± 3.5%; hypotension, 3.5 ± 1.7%; SR reduction, 5.0 ± 2.2%). After adjusting FMD using SR, FMD remained attenuated in the hypotension trial (P = 0.014), but not in the SR reduction trial. Our findings indicate that arterial pressure as well as sympathetic nervous system activation could be an important determinant of FMD. Blunted FMD of peripheral arteries may be a rational response to restore BP and/or prevent further reduction of BP following acute hypotension in healthy humans.
Identifiants
pubmed: 31701274
doi: 10.1007/s00421-019-04260-0
pii: 10.1007/s00421-019-04260-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
161-169Subventions
Organisme : Japanese Ministry of Education, Culture, Sports, Science.
ID : 16K16432
Références
J Hypertens. 2012 Jul;30(7):1399-405
pubmed: 22525207
Clin Sci (Lond). 2007 Jun;112(6):353-61
pubmed: 17129210
Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H2-12
pubmed: 20952670
J Appl Physiol (1985). 2017 Nov 1;123(5):1386-1396
pubmed: 28860174
Hypertension. 2014 Feb;63(2):376-82
pubmed: 24277765
J Am Coll Cardiol. 2002 Feb 20;39(4):683-8
pubmed: 11849869
Exp Physiol. 2014 Oct;99(10):1439-48
pubmed: 25037565
Psychosom Med. 2004 Mar-Apr;66(2):153-64
pubmed: 15039499
Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1894-901
pubmed: 19729606
J Appl Physiol (1985). 1997 Jun;82(6):1785-93
pubmed: 9173942
Anatol J Cardiol. 2016 Sep;16(9):701-6
pubmed: 26680551
Cardiovasc Res. 1999 Aug 15;43(3):739-43
pubmed: 10690345
J Appl Physiol (1985). 2018 May 1;124(5):1326-1332
pubmed: 29446714
Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3122-9
pubmed: 16844924
Scand J Gastroenterol. 2018 Feb;53(2):193-199
pubmed: 29272958
Expert Rev Cardiovasc Ther. 2014 Dec;12(12):1387-9
pubmed: 25410020
J Am Coll Cardiol. 2000 Jul;36(1):213-8
pubmed: 10898437
Stroke. 2008 Jul;39(7):1979-87
pubmed: 18451346
Ann Vasc Dis. 2014;7(2):109-19
pubmed: 24995054
Circ Res. 1993 Feb;72(2):239-45
pubmed: 8418981
Circ Res. 1974 Apr;34(4):515-24
pubmed: 4826928
Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1446-53
pubmed: 16284236
Am J Physiol Regul Integr Comp Physiol. 2014 May 15;306(10):R747-51
pubmed: 24598464
Cardiology. 2016;134(2):65-71
pubmed: 26928301
Pharmacol Ther. 2005 May;106(2):209-20
pubmed: 15866320
J Appl Physiol (1985). 2014 May 15;116(10):1300-7
pubmed: 24699856
J Biotechnol. 2008 Jan 20;133(2):239-44
pubmed: 17850909
Atherosclerosis. 2016 May;248:97-109
pubmed: 26994427
Hypertension. 2011 Mar;57(3):363-9
pubmed: 21263128
Clin Sci (Lond). 2001 Dec;101(6):629-35
pubmed: 11724650
Circulation. 2000 Nov 14;102(20):2473-8
pubmed: 11076819
J Mol Cell Cardiol. 2001 Oct;33(10):1805-14
pubmed: 11603923
Hypertension. 2008 Feb;51(2):203-10
pubmed: 18086954
Br Med J. 1932 May 14;1(3723):873-6
pubmed: 20776843
J Appl Physiol (1985). 2007 Apr;102(4):1510-9
pubmed: 17170205
Exp Physiol. 2016 Aug 1;101(8):1040-9
pubmed: 27228963
Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1279-H1286
pubmed: 30118339
Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2524-32
pubmed: 11356607
Europace. 2010 Jul;12(7):987-90
pubmed: 20466816
Med Sci Sports Exerc. 2018 Jan;50(1):124-130
pubmed: 28817509
Front Physiol. 2014 Jun 30;5:241
pubmed: 25071587
Am J Cardiol. 2010 Aug 1;106(3):378-82
pubmed: 20643249
Stroke. 1989 Jan;20(1):45-52
pubmed: 2492126
Cardiovasc Ultrasound. 2008 Sep 04;6:44
pubmed: 18771594
Biomed Pharmacother. 2006 Sep;60(8):448-52
pubmed: 16930937
Circulation. 2005 Feb 1;111(4):494-8
pubmed: 15687139
Circ Res. 1997 Jul;81(1):1-7
pubmed: 9201021
Vasc Cell. 2015 Sep 18;7:8
pubmed: 26388991
Blood Press. 2002;11(1):22-7
pubmed: 11926347
J Physiol. 2015 Dec 1;593(23):5145-56
pubmed: 26437709
Ann Thorac Surg. 2000 Feb;69(2):480-5
pubmed: 10735684
J Vasc Res. 1992 Sep-Oct;29(5):396-404
pubmed: 1358232