Optimizing Secukinumab Treatment in Psoriasis with Concomitant Methotrexate Administration: Minireview and A Case Report.
Methotrexate concomitant therapy
Psoriasis
Psoriatic arthritis
Secukinumab
Journal
Case reports in dermatology
ISSN: 1662-6567
Titre abrégé: Case Rep Dermatol
Pays: Switzerland
ID NLM: 101517685
Informations de publication
Date de publication:
Historique:
received:
02
07
2019
accepted:
03
07
2019
entrez:
31
10
2019
pubmed:
31
10
2019
medline:
31
10
2019
Statut:
epublish
Résumé
The introduction of biologic drugs for the treatment of moderate-to-severe psoriasis resulted in a significant improvement in patients' health. Moreover, treatment regimens in psoriatic patients should be tailored to meet specific needs based on disease severity, impact on quality of life, response to previous therapies and presence of comorbidities. Combination therapy of biologic agents with conventional systemic drugs has been proposed to optimize psoriasis treatment outcomes in unresponsive or partial responsive severe psoriatic patients. We report the case of a patient with a long-standing recalcitrant plaque psoriasis and psoriatic arthritis who was administered secukinumab combined with methotrexate. The patient had previously been treated with several topical and systemic therapies associated with loss of efficacy or adverse event occurrence. Approximately 24 weeks after starting the combined regimen, significant clearance of psoriasis and reduction of arthritis ensued, with no drug side effects.
Identifiants
pubmed: 31662734
doi: 10.1159/000501994
pii: cde-0011-0017
pmc: PMC6816129
doi:
Types de publication
Case Reports
Langues
eng
Pagination
17-22Informations de copyright
Copyright © 2019 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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