STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats.
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ adverse effects
Diclofenac
/ adverse effects
Disease Models, Animal
Duodenal Ulcer
/ chemically induced
Duodenum
/ drug effects
Female
Gastric Mucosa
/ drug effects
Humans
Intestinal Mucosa
/ drug effects
Plant Extracts
/ administration & dosage
Protective Agents
/ administration & dosage
Rats
Rats, Wistar
Stomach Ulcer
/ chemically induced
Treatment Outcome
Diclofenac
Gastro-intestinal lesions
Inflammation
Omeprazole
STW 5
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
21 Oct 2019
21 Oct 2019
Historique:
received:
28
04
2019
revised:
16
08
2019
accepted:
13
09
2019
entrez:
30
10
2019
pubmed:
30
10
2019
medline:
27
2
2020
Statut:
ppublish
Résumé
Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory drugs. However, they are not always effective against both gastric and duodenal lesions and their use is not devoid of side effects. To explore the mechanisms mediating the clinical efficacy of STW 5 in gastro-duodenal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs), exemplified here by diclofenac, in a comparison to omeprazole. Gastro-duodenal lesions were induced in rats by oral administration of diclofenac (5 mg/kg) for 6 successive days. One group was given concurrently STW 5 (5 mL/kg) while another was given omeprazole (20 mg/kg). A day later, animals were sacrificed, stomach and duodenum excised and divided into 2 segments: One for histological examination and one for measuring inflammatory mediators (tumor necrosis factor α, interleukins-1β and 10), oxidative stress enzyme (heme oxygenase-1) and apoptosis regulator (B-cell lymphoma 2). Diclofenac caused overt histological damage in both tissues, associated with parallel changes in all parameters measured. STW 5 and omeprazole effectively prevented these changes, but STW 5 superseded omeprazole in protecting against histological damage, particularly in the duodenum. The findings support the therapeutic usefulness of STW 5 and its superiority over omeprazole as adjuvant therapy to NSAIDs to protect against their possible gastro-duodenal side effects.
Sections du résumé
BACKGROUND
BACKGROUND
Proton pump inhibitors are often used to prevent gastro-intestinal lesions induced by nonsteroidal anti-inflammatory drugs. However, they are not always effective against both gastric and duodenal lesions and their use is not devoid of side effects.
AIM
OBJECTIVE
To explore the mechanisms mediating the clinical efficacy of STW 5 in gastro-duodenal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs), exemplified here by diclofenac, in a comparison to omeprazole.
METHODS
METHODS
Gastro-duodenal lesions were induced in rats by oral administration of diclofenac (5 mg/kg) for 6 successive days. One group was given concurrently STW 5 (5 mL/kg) while another was given omeprazole (20 mg/kg). A day later, animals were sacrificed, stomach and duodenum excised and divided into 2 segments: One for histological examination and one for measuring inflammatory mediators (tumor necrosis factor α, interleukins-1β and 10), oxidative stress enzyme (heme oxygenase-1) and apoptosis regulator (B-cell lymphoma 2).
RESULTS
RESULTS
Diclofenac caused overt histological damage in both tissues, associated with parallel changes in all parameters measured. STW 5 and omeprazole effectively prevented these changes, but STW 5 superseded omeprazole in protecting against histological damage, particularly in the duodenum.
CONCLUSION
CONCLUSIONS
The findings support the therapeutic usefulness of STW 5 and its superiority over omeprazole as adjuvant therapy to NSAIDs to protect against their possible gastro-duodenal side effects.
Identifiants
pubmed: 31660030
doi: 10.3748/wjg.v25.i39.5926
pmc: PMC6815791
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Plant Extracts
0
Protective Agents
0
iberogast
0
Diclofenac
144O8QL0L1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5926-5935Informations de copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: Mohamed T Khayyal reports grants from Steigerwald Arzneimittelwerk GmbH, Bayer Consumer Health, during the conduct of the study; Olaf Kelber, Ramy M. Ammar, Heba Abdel-Aziz are employed by Steigerwald Arzneimittelwerk GmbH, Bayer Consumer Health, Darmstadt, Germany; all other authors have no conflict of interest.
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