Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast.
Aging
Curcumin
Hypertrophy
Oxidative stress
Yeast
Journal
Biogerontology
ISSN: 1573-6768
Titre abrégé: Biogerontology
Pays: Netherlands
ID NLM: 100930043
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
20
08
2019
accepted:
22
10
2019
pubmed:
30
10
2019
medline:
15
12
2020
entrez:
30
10
2019
Statut:
ppublish
Résumé
Curcumin is a biologically active compound of vegetable origin which has a hormetic effect. Pro-health and anti-aging properties of curcumin have been known for years. The main benefit of curcumin is thought to be its anti-oxidative action. Despite vast amount of data confirming age-delaying activity of curcumin in various groups of organisms, so far little has been discovered about curcumin's impact on cell aging in the experimental model of the Saccharomyces cerevisiae budding yeast. We have been able to demonstrate that curcumin significantly increases oxidative stress and accelerates replicative and chronological aging of yeast cells devoid of anti-oxidative protection (with SOD1 and SOD2 gene deletion) and deprived of DNA repair mechanisms (RAD52). Interestingly, curcumin delays aging, probably through hormesis, of the wild-type strain BY4741.
Identifiants
pubmed: 31659616
doi: 10.1007/s10522-019-09846-x
pii: 10.1007/s10522-019-09846-x
pmc: PMC6942599
doi:
Substances chimiques
Antioxidants
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109-123Références
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