Lesions causing hallucinations localize to one common brain network.


Journal

Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835

Informations de publication

Date de publication:
04 2021
Historique:
received: 05 06 2019
accepted: 17 10 2019
revised: 26 09 2019
pubmed: 30 10 2019
medline: 15 5 2021
entrez: 30 10 2019
Statut: ppublish

Résumé

The brain regions responsible for hallucinations remain unclear. We studied 89 brain lesions causing hallucinations using a recently validated technique termed lesion network mapping. We found that hallucinations occurred following lesions to a variety of different brain regions, but these lesion locations fell within a single functionally connected brain network. This network was defined by connectivity to the cerebellar vermis, inferior cerebellum (bilateral lobule X), and the right superior temporal sulcus. Within this single hallucination network, additional connections with the lesion location dictated the sensory modality of the hallucination: lesions causing visual hallucinations were connected to the lateral geniculate nucleus in the thalamus while lesions causing auditory hallucinations were connected to the dentate nucleus in the cerebellum. Our results suggest that lesions causing hallucinations localize to a single common brain network, but additional connections within this network dictate the sensory modality, lending insight into the causal neuroanatomical substrate of hallucinations.

Identifiants

pubmed: 31659272
doi: 10.1038/s41380-019-0565-3
pii: 10.1038/s41380-019-0565-3
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1299-1309

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH113929
Pays : United States

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Auteurs

Na Young Kim (NY)

Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. Kny8452@yuhs.ac.
Berenson-Allen Center for Non-Invasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Kny8452@yuhs.ac.

Joey Hsu (J)

Berenson-Allen Center for Non-Invasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Daniel Talmasov (D)

Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, New York University School of Medicine, New York, NY, USA.

Juho Joutsa (J)

Berenson-Allen Center for Non-Invasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Turku Brain and Mind Center, Department of Neurology, University of Turku, Turku, Finland.
Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland.

Louis Soussand (L)

Berenson-Allen Center for Non-Invasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Ona Wu (O)

Athinoula A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA.

Natalia S Rost (NS)

J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.

Estrella Morenas-Rodríguez (E)

Department of Neurology, Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau (HSCSP), Universidad Autónoma de Barcelona, Barcelona, Spain.
German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

Joan Martí-Fàbregas (J)

Department of Neurology, Biomedical Research Institute (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau (HSCSP), Universidad Autónoma de Barcelona, Barcelona, Spain.

Alvaro Pascual-Leone (A)

Berenson-Allen Center for Non-Invasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Institut Guttmann de Neurorehabilitació, Universitat Autonoma de Barcelona, Badalona, Spain.

Philip R Corlett (PR)

Department of Psychiatry, Clinical Neuroscience Research Unit, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA.

Michael D Fox (MD)

Berenson-Allen Center for Non-Invasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. foxmdphd@gmail.com.
Athinoula A. Martinos Centre for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA. foxmdphd@gmail.com.

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