Intralesional EBV-DNA load as marker of prognosis for nasopharyngeal cancer.
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ metabolism
DNA, Viral
/ metabolism
Disease-Free Survival
Epstein-Barr Virus Infections
/ metabolism
Female
Herpesvirus 4, Human
/ metabolism
Humans
Male
Middle Aged
Nasopharyngeal Neoplasms
/ metabolism
Neoplasm Staging
Retrospective Studies
Survival Rate
Viral Load
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 10 2019
28 10 2019
Historique:
received:
07
06
2019
accepted:
07
10
2019
entrez:
30
10
2019
pubmed:
30
10
2019
medline:
29
10
2020
Statut:
epublish
Résumé
Nasopharyngeal cancer (NPC) is associated with the Epstein-Barr virus (EBV). The clinical presentation and prognosis of NPC is well described, but not in relation to intralesional EBV-DNA load. In a retrospective design, 48 patients with NPC were examined. Patient history was re-evaluated, and diagnostic biopsies were re-examined. Furthermore, intralesional EBV-DNA was quantitated and HPV status determined. Cancer stage, disease-free survival (DFS), and overall survival (OS) were assessed. Of the 48 patients, 36 (75%) patients featured lesions that were positive for EBER (Epstein-Barr virus-encoded small RNA) and 40 (83%) were positive for EBV-DNA. Seven patients (15%) were HPV positive. The levels of EBV-DNA ranged from 0.0005 to 94617 copies/cell. An EBV-DNA load of more than 70 copies/cell was associated with a prolonged DFS for EBV-DNA positive patients treated with curative intent (p = 0.046). In conclusion, the EBV-DNA load in NPC lesions appears to vary greatly. For patients with EBV-DNA positive NPC treated with curative intent, an EBV-DNA load of more than 70 copies/cell is associated with a better outcome in terms of 7-year DFS.
Identifiants
pubmed: 31659192
doi: 10.1038/s41598-019-51767-9
pii: 10.1038/s41598-019-51767-9
pmc: PMC6817933
doi:
Substances chimiques
Biomarkers, Tumor
0
DNA, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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