Synthesis of thiazolidin-4-ones and thiazinan-4-ones from 1-(2-aminoethyl)pyrrolidine as acetylcholinesterase inhibitors.
Acetylcholinesterase
/ metabolism
Animals
Cerebral Cortex
/ drug effects
Cholinesterase Inhibitors
/ chemical synthesis
Dose-Response Relationship, Drug
Hippocampus
/ drug effects
Molecular Structure
Rats
Rats, Wistar
Structure-Activity Relationship
Thiazines
/ chemical synthesis
Thiazolidines
/ chemical synthesis
Thiazolidin-4-ones
acetylcholinesterase inhibitors
astrocytes
pyrrolidine
thiazinan-4-ones
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
25
10
2019
pubmed:
28
10
2019
medline:
14
1
2020
Statut:
ppublish
Résumé
The present study describes the synthesis of a novel series of thiazolidin-4-one and thiazinan-4-one using 1-(2-aminoethyl)pyrrolidine as amine precursor. All compounds were synthesised by one-pot three component cyclocondensation reaction from the amine, a substituted benzaldehyde and a mercaptocarboxylic acid. The compounds were obtained in moderate to good yields and were identified and characterised by
Identifiants
pubmed: 31645149
doi: 10.1080/14756366.2019.1680659
pmc: PMC6818106
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Thiazines
0
Thiazolidines
0
Acetylcholinesterase
EC 3.1.1.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
31-41Références
Colomb Med (Cali). 2016 Dec 30;47(4):203-212
pubmed: 28293044
Chem Biol Drug Des. 2017 Nov;90(5):883-891
pubmed: 28434186
J Med Chem. 2014 Dec 26;57(24):10257-74
pubmed: 25255204
Arzneimittelforschung. 2006;56(10):678-81
pubmed: 17225562
Eur J Med Chem. 2013 Apr;62:556-63
pubmed: 23422935
Biotechnol Adv. 2017 Mar - Apr;35(2):178-216
pubmed: 28043897
Front Aging Neurosci. 2019 Aug 20;11:220
pubmed: 31481890
Bioorg Med Chem Lett. 2007 Jul 1;17(13):3765-8
pubmed: 17451950
Bioorg Med Chem. 2014 Feb 15;22(4):1262-7
pubmed: 24485122
Anal Biochem. 1976 May 7;72:248-54
pubmed: 942051
J Enzyme Inhib Med Chem. 2019 Dec;34(1):197-203
pubmed: 30482059
J Enzyme Inhib Med Chem. 2007 Aug;22(4):417-24
pubmed: 17847707
Eur J Med Chem. 2016 Nov 29;124:574-582
pubmed: 27614406
Biomed Res Int. 2016;2016:2589276
pubmed: 27547756
J Neurochem. 2017 Aug;142 Suppl 2:19-25
pubmed: 28503857
Curr Top Med Chem. 2019;19(4):264-275
pubmed: 30706815
Eur J Med Chem. 2018 Jan 20;144:544-556
pubmed: 29289880
J Enzyme Inhib Med Chem. 2017 Dec;32(1):572-587
pubmed: 28133981
Eur J Med Chem. 2013 May;63:611-20
pubmed: 23567949
J Formos Med Assoc. 2016 Jan;115(1):3-10
pubmed: 26220908
J Biochem Mol Toxicol. 2014 Sep;28(9):425-32
pubmed: 24939323
Clin Med (Lond). 2016 Jun;16(3):247-53
pubmed: 27251914
Brain Res. 1999 Jul 3;833(2):142-9
pubmed: 10375689
Eur J Med Chem. 2018 Jan 1;143:1028-1038
pubmed: 29232580
Biochem Pharmacol. 1961 Jul;7:88-95
pubmed: 13726518
Curr Neuropharmacol. 2016;14(1):101-15
pubmed: 26813123
Int J Nanomedicine. 2019 Jul 19;14:5541-5554
pubmed: 31410002
Eur J Med Chem. 2014 Jan 24;72:52-77
pubmed: 24355348
Curr Med Chem. 2015;22(3):373-404
pubmed: 25386820
Exp Parasitol. 2018 Sep;192:60-64
pubmed: 30040962
Eur J Med Chem. 2016 Aug 8;118:259-65
pubmed: 27131068