The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus.
Huntington's disease
enhanced sampling
misfolding disease
molecular dynamics
peptide folding
phosphorylation
post-translational modifications
Journal
Frontiers in molecular biosciences
ISSN: 2296-889X
Titre abrégé: Front Mol Biosci
Pays: Switzerland
ID NLM: 101653173
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
06
2019
accepted:
11
09
2019
entrez:
22
10
2019
pubmed:
22
10
2019
medline:
22
10
2019
Statut:
epublish
Résumé
Huntington disease is a neurodegenerative disease characterized by a polymorphic tract of polyglutamine repeats in exon 1 of the huntingtin protein, which is thought to be responsible for protein aggregation and neuronal death. The polyglutamine tract is preceded by a 17-residue sequence that is intrinsically disordered. This region is subject to phosphorylation, acetylation and other post-translational modifications
Identifiants
pubmed: 31632982
doi: 10.3389/fmolb.2019.00095
pmc: PMC6779701
doi:
Types de publication
Journal Article
Langues
eng
Pagination
95Subventions
Organisme : Medical Research Council
ID : MC_U117584256
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Yalinca, Gehin, Oleinikovas, Lashuel, Gervasio and Pastore.
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