Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 10 2019
17 10 2019
Historique:
received:
26
04
2019
accepted:
17
09
2019
entrez:
19
10
2019
pubmed:
19
10
2019
medline:
25
1
2020
Statut:
epublish
Résumé
Acetylation of histone H3K23 has emerged as an essential posttranslational modification associated with cancer and learning and memory impairment, yet our understanding of this epigenetic mark remains insufficient. Here, we identify the native MORF complex as a histone H3K23-specific acetyltransferase and elucidate its mechanism of action. The acetyltransferase function of the catalytic MORF subunit is positively regulated by the DPF domain of MORF (MORF
Identifiants
pubmed: 31624313
doi: 10.1038/s41467-019-12551-5
pii: 10.1038/s41467-019-12551-5
pmc: PMC6797804
doi:
Substances chimiques
Histones
0
Histone Acetyltransferases
EC 2.3.1.48
KAT6B protein, human
EC 2.3.1.48
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4724Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM100907
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM135671
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM106416
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM126900
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA204020
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125195
Pays : United States
Organisme : NIH HHS
ID : S10 OD012033
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM121584
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
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