Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits without Conspicuous Mesangial Proliferation, Complicated with Squamous Cell Lung Carcinoma.
lung carcinoma
paraneoplastic syndrome
proliferative glomerulonephritis with monoclonal immunoglobulin deposits
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Feb 2020
15 Feb 2020
Historique:
pubmed:
16
10
2019
medline:
4
9
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
We performed a renal biopsy for nephrotic syndrome in a patient with squamous cell lung carcinoma, which can worsen the prognosis. Chemoradiation therapy was effective for the cancer and proteinuria; we thus inferred that the nephrotic syndrome had been closely associated with the carcinoma. A pathological analysis of the kidney showed monoclonality for λ chain, satisfying the diagnostic criteria of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID); however, conspicuous mesangial proliferation was not observed. This is the first case of PGNMID complicated with lung carcinoma; furthermore, our findings underscore the importance of examining renal lesions and assessing monoclonality in cancer patients.
Identifiants
pubmed: 31611527
doi: 10.2169/internalmedicine.2993-19
pmc: PMC7056369
doi:
Substances chimiques
Antibodies, Monoclonal
0
Immunoglobulin G
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
557-562Références
Ann Intern Med. 1966 Jan;64(1):41-51
pubmed: 5900782
J Am Soc Nephrol. 2013 Jan;24(1):26-30
pubmed: 23138480
Kidney Int. 1977 May;11(5):297-303
pubmed: 197291
Kidney Int. 2013 Jul;84(1):34-44
pubmed: 23364518
Kidney Int. 2012 Oct;82(7):797-804
pubmed: 22673885
Kidney Int. 2015 Apr;87(4):698-711
pubmed: 25607108
Kidney Int Rep. 2017 Jul 29;2(6):1141-1148
pubmed: 29270522
Pathol Oncol Res. 2018 Jan;24(1):1-10
pubmed: 28160197
Nephrol Dial Transplant. 2008 Dec;23(12):3888-94
pubmed: 18596130
Nephrol Dial Transplant. 2001;16 Suppl 6:13-4
pubmed: 11568228
Clin J Am Soc Nephrol. 2012 Oct;7(10):1701-12
pubmed: 22904123
Clin J Am Soc Nephrol. 2011 Jan;6(1):122-32
pubmed: 20876681
J Am Soc Nephrol. 2009 Sep;20(9):2055-64
pubmed: 19470674
Br Med J. 1922 Dec 23;2(3234):1201-1208.2
pubmed: 20770949