Pyonitrins A-D: Chimeric Natural Products Produced by
Animals
Antifungal Agents
/ chemistry
Bacterial Proteins
/ genetics
Biological Products
/ chemistry
Biosynthetic Pathways
/ genetics
Candida albicans
/ drug effects
Candidiasis
/ drug therapy
Chromatography, High Pressure Liquid
Drug Evaluation, Preclinical
/ methods
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Phenols
/ metabolism
Pseudomonas
/ genetics
Pyrrolnitrin
/ biosynthesis
Thiazoles
/ metabolism
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
30 10 2019
30 10 2019
Historique:
pubmed:
11
10
2019
medline:
5
11
2020
entrez:
11
10
2019
Statut:
ppublish
Résumé
Bacterial symbionts frequently provide chemical defenses for their hosts, and such systems can provide discovery pathways to new antifungals and structurally intriguing metabolites. This report describes a small family of naturally occurring small molecules with chimeric structures and a mixed biosynthesis that features an unexpected but key nonenzymatic step. An insect-associated
Identifiants
pubmed: 31600443
doi: 10.1021/jacs.9b09739
pmc: PMC6823628
doi:
Substances chimiques
Antifungal Agents
0
Bacterial Proteins
0
Biological Products
0
Phenols
0
Thiazoles
0
pyochelin
69772-54-9
Pyrrolnitrin
N0P24B6EDQ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
17098-17101Subventions
Organisme : NIAID NIH HHS
ID : U19 AI109673
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142720
Pays : United States
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