Association between cardiovascular risk factors and the diameter of the main pulmonary artery in asymptomatic population in the Appalachian region.
Pulmonary artery (PA)
cardiovascular disease (CV disease)
hypertension
risk factors
Journal
Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
entrez:
28
9
2019
pubmed:
29
9
2019
medline:
29
9
2019
Statut:
ppublish
Résumé
Pulmonary artery (PA) diameter may be altered in association with cardiovascular (CV) risk factors as noted in aorta in systemic hypertension. The flow of blood from the right ventricle to the PA and all the way to the capillary level depends on the pulmonary vascular resistance and to a lesser extent compliance and impedance of the PA, which are the fundamental conduit for maintenance of the right heart hemodynamics. Our objective is to determine the association between CV risk factors and the main pulmonary artery (MPA) diameter. The study population are asymptomatic individuals with no known diagnosis of CV diseases in central Appalachia (n=1,282). Adults aged 18 years or older were eligible for the screening if they were referred by a physician. For self-referral, only males aged ≥45 years and females aged ≥55 years were eligible. Unadjusted and adjusted linear regression analyses were performed. The mean MPA diameter was significantly higher among males compared to females (27.19±4.20 MPA diameter was significantly associated with age, sex, and BMI. Further prospective studies are needed to correlate computed tomography (CT) measurement of MPA diameter with pulmonary pressure as assessed by echocardiogram to diagnose pulmonary hypertension (PH).
Sections du résumé
BACKGROUND
BACKGROUND
Pulmonary artery (PA) diameter may be altered in association with cardiovascular (CV) risk factors as noted in aorta in systemic hypertension. The flow of blood from the right ventricle to the PA and all the way to the capillary level depends on the pulmonary vascular resistance and to a lesser extent compliance and impedance of the PA, which are the fundamental conduit for maintenance of the right heart hemodynamics. Our objective is to determine the association between CV risk factors and the main pulmonary artery (MPA) diameter.
METHODS
METHODS
The study population are asymptomatic individuals with no known diagnosis of CV diseases in central Appalachia (n=1,282). Adults aged 18 years or older were eligible for the screening if they were referred by a physician. For self-referral, only males aged ≥45 years and females aged ≥55 years were eligible. Unadjusted and adjusted linear regression analyses were performed.
RESULTS
RESULTS
The mean MPA diameter was significantly higher among males compared to females (27.19±4.20
CONCLUSIONS
CONCLUSIONS
MPA diameter was significantly associated with age, sex, and BMI. Further prospective studies are needed to correlate computed tomography (CT) measurement of MPA diameter with pulmonary pressure as assessed by echocardiogram to diagnose pulmonary hypertension (PH).
Identifiants
pubmed: 31559048
doi: 10.21037/jtd.2019.08.09
pii: jtd-11-08-3435
pmc: PMC6753455
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3435-3442Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no conflicts of interest to declare.
Références
Br J Radiol. 1998 Oct;71(850):1018-20
pubmed: 10211060
AJR Am J Roentgenol. 1979 Jul;133(1):75-81
pubmed: 110073
Pharmacol Ther. 2001 Oct;92(1):1-20
pubmed: 11750034
Circulation. 1960 Jul;22:130-7
pubmed: 14422672
J Appl Physiol. 1962 Mar;17:205-8
pubmed: 14484299
Am J Med. 2004 Mar 15;116(6):369-74
pubmed: 15006585
AJR Am J Roentgenol. 2007 Feb;188(2):W126-34
pubmed: 17242217
Transplant Proc. 2007 Sep;39(7):2405-8
pubmed: 17889203
Isr Med Assoc J. 2008 Feb;10(2):117-20
pubmed: 18432023
JACC Cardiovasc Imaging. 2009 Mar;2(3):286-95
pubmed: 19356573
Chest. 2010 Feb;137(2):376-87
pubmed: 19837821
Radiology. 2010 Feb;254(2):609-16
pubmed: 20093532
J Appl Physiol (1985). 1991 Feb;70(2):859-68
pubmed: 2022578
Chest. 2011 Jul;140(1):19-26
pubmed: 21393391
AJR Am J Roentgenol. 2011 Apr;196(4):788-94
pubmed: 21427326
BMC Med Imaging. 2011 Mar 29;11:7
pubmed: 21447184
Circ Cardiovasc Imaging. 2012 Jan;5(1):147-54
pubmed: 22178898
J Thorac Imaging. 2013 Mar;28(2):96-103
pubmed: 23096163
AJR Am J Roentgenol. 2013 Jun;200(6):W581-92
pubmed: 23701088
Pulm Circ. 2013 Apr;3(2):363-8
pubmed: 24015337
J Am Coll Cardiol. 2013 Dec 24;62(25 Suppl):D42-50
pubmed: 24355641
Chest. 2014 May;145(5):1064-1070
pubmed: 24356904
J Comput Assist Tomogr. 2014 Mar-Apr;38(2):163-8
pubmed: 24448503
Ann Am Thorac Soc. 2014 Dec;11(10):1623-32
pubmed: 25406836
PLoS One. 2015 May 08;10(5):e0126646
pubmed: 25955036
JACC Heart Fail. 2015 Jun;3(6):467-474
pubmed: 26046840
Ann Am Thorac Soc. 2016 Feb;13(2):276-84
pubmed: 26848601
Lung. 2016 Oct;194(5):813-9
pubmed: 27423782
J Appl Physiol (1985). 1963 May 01;18(3):557-559
pubmed: 31095349
Clin Radiol. 1988 Sep;39(5):486-9
pubmed: 3180668
Ann Intern Med. 1987 Aug;107(2):216-23
pubmed: 3605900
Circ Res. 1969 Dec;25(6):637-49
pubmed: 5364641
Circ Res. 1971 Jul;29(1):40-50
pubmed: 5561407
Circ Res. 1980 Dec;47(6):902-10
pubmed: 6108164
Ann Biomed Eng. 1984;12(2):119-34
pubmed: 6439084
Invest Radiol. 1984 Jan-Feb;19(1):16-22
pubmed: 6706516
Chest. 1998 May;113(5):1250-6
pubmed: 9596302