Stability of Biological Activity of Frozen β-lactams over Time as Assessed by Time-Lapsed Broth Microdilutions.
Beta-lactams
antimicrobial
antimicrobial stability
frozen drugs
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
25 Sep 2019
25 Sep 2019
Historique:
received:
27
08
2019
revised:
20
09
2019
accepted:
22
09
2019
entrez:
28
9
2019
pubmed:
29
9
2019
medline:
29
9
2019
Statut:
epublish
Résumé
To evaluate the antimicrobial agent's stability stored at -80 °C, six β-lactams (meropenem, ertapenem, imipenem, ceftriaxone, ceftazidime, and piperacillin-tazobactam) were studied using the broth microdilution (BMD). The minimum inhibitory concentration (MIC) remained accurate with the same amount of frozen drug for at least six months. Thereafter, there was a diminishing drug concentration due to instability. At this temperature, most β-lactams can be frozen as a stock concentration for up to six months without a significant loss in antibiotic activity.
Identifiants
pubmed: 31557817
pii: antibiotics8040165
doi: 10.3390/antibiotics8040165
pmc: PMC6963782
pii:
doi:
Types de publication
Letter
Langues
eng
Références
Biotechnol J. 2019 Jan;14(1):e1700750
pubmed: 30024110
Sci Rep. 2019 Jan 18;9(1):237
pubmed: 30659207