Thyroid autoimmunity and risk of post-partum depression: a systematic review and meta-analysis of longitudinal studies.
Anti-thyroperoxidase antibodies
Cohort studies
Hypothyroidism
Post-partum depression
Thyroiditis
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
19
07
2019
accepted:
16
09
2019
pubmed:
26
9
2019
medline:
21
11
2020
entrez:
26
9
2019
Statut:
ppublish
Résumé
The aim of this study was to systematically investigate whether, and to what extent, the detection of thyroid autoimmunity during pregnancy and in the weeks after childbirth is associated with an increased risk of developing post-partum depression (PPD), a condition associated with possible adverse outcomes for both mother and offspring. We performed a systematic review and meta-analysis of longitudinal studies, assessing the incidence of PPD in women with and without anti-thyroperoxidase antibody (TPOAb) positivity. We searched MEDLINE, EMBASE, Web of Science, Cochrane Library, and CINAHL. Methodological quality of the studies was assessed by the Newcastle-Ottawa Scale. In the presence of even modest between-studies heterogeneity, assessed by Cochrane Q and I Five included studies provided information on 449 women with TPOAb-positive and 2483 TPOAb-negative women. Pooled RR indicated a significantly increased risk to develop PPD in TPOAb-positive group (RR 1.49, 95% CI 1.11-2.00; P = 0.008; I Thyroid autoimmunity during pregnancy and in the weeks after childbirth is associated with an increased risk of developing PPD. Further well-designed studies are warranted to confirm this association and elucidate underlying pathophysiological mechanisms. CRD42019129643.
Identifiants
pubmed: 31552596
doi: 10.1007/s40618-019-01120-8
pii: 10.1007/s40618-019-01120-8
doi:
Substances chimiques
Autoantibodies
0
Iodide Peroxidase
EC 1.11.1.8
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
271-277Références
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