Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation.

Animals B-Lymphocytes / metabolism Cells, Cultured Class I Phosphatidylinositol 3-Kinases / genetics Enteritis / genetics Inflammation / genetics Interleukin-10 / metabolism Intestines / drug effects Mice Mice, Inbred C57BL Mice, Knockout Microbiota / physiology Signal Transduction / genetics
IL-10 PI3Kδ inflammatory bowel diseases regulatory B cells residential microbiota

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
21 09 2019
Historique:
received: 30 08 2019
revised: 18 09 2019
accepted: 20 09 2019
entrez: 25 9 2019
pubmed: 25 9 2019
medline: 17 6 2020
Statut: epublish

Résumé

The phosphoinositide 3-kinase catalytic subunit p110δ (PI3Kδ) gene maps to a human inflammatory bowel diseases (IBD) susceptibility locus, and genetic deletion of PI3Kδ signaling causes spontaneous colitis in mice. However, little is known regarding the role of PI3Kδ on IL-10-producing B cells that help regulate mucosal inflammation in IBD. We investigated the role of PI3Kδ signaling in B cell production of IL-10, following stimulation by resident bacteria and B cell regulatory function against colitis. In vitro, B cells from PI3Kδ

Identifiants

DOI: 10.3390/cells8101121 PMID: 31546615 PMC: PMC6829312
pubmed: 31546615
pii: cells8101121
doi: 10.3390/cells8101121
pmc: PMC6829312
pii:
doi:

Substances chimiques

Interleukin-10 130068-27-8
Class I Phosphatidylinositol 3-Kinases EC 2.7.1.137
Pik3cd protein, mouse EC 2.7.1.137

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDDK NIH HHS
ID : P01 DK094779
Pays : United States
Organisme : NIH HHS
ID : P40 OD010995
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007737
Pays : United States

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Auteurs

Akihiko Oka (A)

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. akihiko_oka@med.unc.edu.
Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan. akihiko_oka@med.unc.edu.
ORCID: 0000-0001-6451-8413

Yoshiyuki Mishima (Y)

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. mtmtyui@med.shimane-u.ac.jp.
Department of Internal Medicine II, Shimane University Faculty of Medicine, Izumo, Shimane 693-8501, Japan. mtmtyui@med.shimane-u.ac.jp.
ORCID: 0000-0001-5261-6411

Bo Liu (B)

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. bo_liu@med.unc.edu.

Jeremy W Herzog (JW)

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. jeremy_herzog@med.unc.edu.

Erin C Steinbach (EC)

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. erin_klein@med.unc.edu.
Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. erin_klein@med.unc.edu.
ORCID: 0000-0002-6165-8928

Taku Kobayashi (T)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. kobataku@insti.kitasato-u.ac.jp.
Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo 108-8642, Japan. kobataku@insti.kitasato-u.ac.jp.

Scott E Plevy (SE)

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. scott.plevy@synlogictx.com.
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. scott.plevy@synlogictx.com.
Synlogic Therapeutics, Boston, MA 02139, USA. scott.plevy@synlogictx.com.

R Balfour Sartor (RB)

Center for Gastrointestinal Biology and Disease, Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbs@med.unc.edu.
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. rbs@med.unc.edu.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Cellules › Cellules cultivées › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Phosphatidylinositol-4-phosphate 3-kinase › Phosphatidylinositol 3-kinases de classe I › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Entérite › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-10 › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Système digestif › Tube digestif › Intestins › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Phosphoinositide 3-Kinase P110δ-Signaling Is...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Phosphoinositide 3-Kinase P110δ-Signaling Is...