Neonatal Soft Tissue Sarcoma with YWHAE-NUTM2B Fusion.
Cancer biology
Chemotherapy
Fusion transcript
Neonatal
Sarcoma
Journal
Case reports in oncology
ISSN: 1662-6575
Titre abrégé: Case Rep Oncol
Pays: Switzerland
ID NLM: 101517601
Informations de publication
Date de publication:
Historique:
received:
18
07
2019
accepted:
18
07
2019
entrez:
24
9
2019
pubmed:
24
9
2019
medline:
24
9
2019
Statut:
epublish
Résumé
Neonatal soft tissues sarcoma is a rare entity that comprises heterogeneous types of tumors. In this article we describe a neonatal case of round-cell sarcoma with an YWHAE-NUTM2B fusion gene. The patient was treated just after birth with neoadjuvant chemotherapy, then surgical resection, but evolution was quickly fatal. This fusion transcript has been reported in endometrial stromal sarcomas and clear cells renal sarcomas but its description in small round-cell sarcomas is recent. To our knowledge, this is the first case report describing this translocation in a newborn patient with soft tissues sarcoma and its clinical tumoral evolution.
Identifiants
pubmed: 31543780
doi: 10.1159/000502227
pii: cro-0012-0631
pmc: PMC6738155
doi:
Types de publication
Case Reports
Langues
eng
Pagination
631-638Déclaration de conflit d'intérêts
The authors have no conflicts of interest to report.
Références
Mol Cell Biol. 2006 Sep;26(18):6880-9
pubmed: 16943429
Eur J Cancer. 2010 Sep;46(13):2449-56
pubmed: 20538453
Semin Fetal Neonatal Med. 2012 Aug;17(4):231-238
pubmed: 22633289
Histopathology. 2014 Jan;64(1):2-11
pubmed: 24164390
Lancet Oncol. 2013 Dec;14(13):e609-20
pubmed: 24275134
J Mol Diagn. 2014 May;16(3):361-70
pubmed: 24517889
Pediatr Dev Pathol. 2015 Sep-Oct;18(5):401-4
pubmed: 25751458
Genes Chromosomes Cancer. 2016 Feb;55(2):120-3
pubmed: 26493387
Nat Commun. 2015 Nov 17;6:8891
pubmed: 26573325
Bull Cancer. 2016 Apr;103(4):402-11
pubmed: 26927827
Am J Surg Pathol. 2016 Aug;40(8):1009-20
pubmed: 26945340
Ann Diagn Pathol. 2016 Jun;22:25-32
pubmed: 27180056
Structure. 2016 Oct 4;24(10):1795-1801
pubmed: 27568929
Int J Gynecol Pathol. 2018 Sep;37(5):441-447
pubmed: 28863072
J Pathol. 2018 May;245(1):29-40
pubmed: 29431183