Changes in murine respiratory dynamics induced by aerosolized carfentanil inhalation: Efficacy of naloxone and naltrexone.
Administration, Inhalation
Aerosols
Analgesics, Opioid
/ administration & dosage
Animals
Computer Simulation
Dose-Response Relationship, Drug
Fentanyl
/ administration & dosage
Humans
Lung
/ drug effects
Male
Mice
Models, Biological
Naloxone
/ administration & dosage
Naltrexone
/ administration & dosage
Narcotic Antagonists
/ administration & dosage
Plethysmography, Whole Body
Respiration
/ drug effects
Respiratory Insufficiency
/ chemically induced
Risk Assessment
Carfentanil
Inhalation exposure
Naloxone
Naltrexone
Physiology based pharmacokinetics
Prophylaxis
Respiratory dynamics
Journal
Toxicology letters
ISSN: 1879-3169
Titre abrégé: Toxicol Lett
Pays: Netherlands
ID NLM: 7709027
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
30
07
2019
revised:
26
08
2019
accepted:
14
09
2019
pubmed:
21
9
2019
medline:
23
10
2019
entrez:
21
9
2019
Statut:
ppublish
Résumé
Carfentanil (CRF) is an extremely potent opioid capable of inducing fatal respiratory depression. Naloxone (NX) and naltrexone (NTX) are opioid antagonists for which the efficacy against CRF remains largely unexplored. In this study, the effects of aerosolized CRF on respiratory function were investigated using adult male CD-1 mice. Mice were exposed to 0.4 mg/m
Identifiants
pubmed: 31539569
pii: S0378-4274(19)30283-8
doi: 10.1016/j.toxlet.2019.09.012
pii:
doi:
Substances chimiques
Aerosols
0
Analgesics, Opioid
0
Narcotic Antagonists
0
Naloxone
36B82AMQ7N
Naltrexone
5S6W795CQM
carfentanil
LA9DTA2L8F
Fentanyl
UF599785JZ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-135Informations de copyright
Published by Elsevier B.V.