Predicting and Experimentally Validating Hot-Spot Residues at Protein-Protein Interfaces.

Amino Acids / chemistry Animals Humans Magnetic Resonance Spectroscopy Mice Molecular Dynamics Simulation Mutagenesis, Site-Directed / methods Myeloid Cell Leukemia Sequence 1 Protein / chemistry Nerve Tissue Proteins / chemistry Protein Binding Protein Multimerization Proteins / chemistry Rats SAP90-PSD95 Associated Proteins / chemistry Small Ubiquitin-Related Modifier Proteins / chemistry

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
18 10 2019
Historique:
pubmed: 17 9 2019
medline: 9 4 2020
entrez: 17 9 2019
Statut: ppublish

Résumé

Protein-protein interactions (PPIs) are vital to all biological processes. These interactions are often dynamic, sometimes transient, typically occur over large topographically shallow protein surfaces, and can exhibit a broad range of affinities. Considerable progress has been made in determining PPI structures. However, given the above properties, understanding the key determinants of their thermodynamic stability remains a challenge in chemical biology. An improved ability to identify and engineer PPIs would advance understanding of biological mechanisms and mutant phenotypes and also provide a firmer foundation for inhibitor design.

Identifiants

DOI: 10.1021/acschembio.9b00560 PMID: 31525028 PMC: PMC6804253
pubmed: 31525028
doi: 10.1021/acschembio.9b00560
pmc: PMC6804253
doi:

Substances chimiques

Amino Acids 0
Mcl1 protein, mouse 0
Myeloid Cell Leukemia Sequence 1 Protein 0
Nerve Tissue Proteins 0
Proteins 0
SAP90-PSD95 Associated Proteins 0
Small Ubiquitin-Related Modifier Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2252-2263

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L01386X/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 097827/Z/11/A
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT094232M
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 094232/Z/10/Z
Pays : United Kingdom

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Auteurs

Amaurys A Ibarra (AA)

School of Biochemistry , University of Bristol , Medical Sciences Building, University Walk , Bristol BS8 1TD , U.K.

Gail J Bartlett (GJ)

School of Chemistry , University of Bristol , Cantock's Close , Bristol BS8 1TS , U.K.

Zsöfia Hegedüs (Z)

School of Chemistry , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Som Dutt (S)

School of Chemistry , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Fruzsina Hobor (F)

Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
School of Molecular and Cellular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Katherine A Horner (KA)

School of Chemistry , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Kristina Hetherington (K)

School of Chemistry , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Kirstin Spence (K)

Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
School of Molecular and Cellular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Adam Nelson (A)

School of Chemistry , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Thomas A Edwards (TA)

Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
School of Molecular and Cellular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.

Derek N Woolfson (DN)

School of Biochemistry , University of Bristol , Medical Sciences Building, University Walk , Bristol BS8 1TD , U.K.
School of Chemistry , University of Bristol , Cantock's Close , Bristol BS8 1TS , U.K.
BrisSynBio , University of Bristol , Life Sciences Building, Tyndall Avenue , Bristol BS8 1TQ , U.K.
ORCID: 0000-0002-0394-3202

Richard B Sessions (RB)

School of Biochemistry , University of Bristol , Medical Sciences Building, University Walk , Bristol BS8 1TD , U.K.
BrisSynBio , University of Bristol , Life Sciences Building, Tyndall Avenue , Bristol BS8 1TQ , U.K.
ORCID: 0000-0003-0320-0895

Andrew J Wilson (AJ)

School of Chemistry , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
Astbury Centre for Structural Molecular Biology , University of Leeds , Woodhouse Lane , Leeds LS2 9JT , U.K.
ORCID: 0000-0001-9852-6366

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