LAUDES Study: impact of digital ulcers on hand functional limitation, work productivity and daily activities, in systemic sclerosis patients.
Disability evaluation
Hand
Human activities
Quality of life
Scleroderma and related disorders
Journal
Rheumatology international
ISSN: 1437-160X
Titre abrégé: Rheumatol Int
Pays: Germany
ID NLM: 8206885
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
08
07
2019
accepted:
24
08
2019
pubmed:
16
9
2019
medline:
28
4
2020
entrez:
16
9
2019
Statut:
ppublish
Résumé
The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58 years; p < 0.001) and had more frequently the diffuse subtype of SSc (45 vs. 24%; p = 0.004) than patients without DUs. Patients with DUs showed significantly higher scores in the Cochin Hand Function Scale overall (p < 0.002) and for each of its five dimensions. They also showed higher scores in the Systemic Sclerosis Health Assessment Questionnaire items related to hand function such as, dress and self-care (p < 0.013), eat (p < 0.013) and grip (p < 0.03), and higher Visual Analogic Scale scores for pain (p < 0.013), trouble related with Raynaud's Phenomenon (p < 0.001) and sense of severity (p < 0.004). Impact on daily activities was significantly higher in patients with DUs (p = 0.002), with a non-significant trend to experience higher impact on work productivity (p = 0.07). A high correlation was found between DUs patients and physicians opinion on the impact of DUs (daily life: Pearson R = 0.86; work productivity: Pearson R = 0.87). Study findings show an impaired hand function and increased disability for daily life activities and work productivity in SSc patients with DUs compared with patients without DUs in Spanish population.
Identifiants
pubmed: 31522232
doi: 10.1007/s00296-019-04436-z
pii: 10.1007/s00296-019-04436-z
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1875-1882Investigateurs
Bruno Aspe de la Iglesia
(B)
Julia Barbado Ajo
(J)
Daniel Batista Perdomo
(D)
Emma Beltrán Catalán
(E)
Joaquin Belzunegui Otano
(J)
Jorge Santiago Blanco Rodríguez
(JS)
Manuel Caamaño Freire
(M)
Alberto Cantabrana Alútiz
(A)
Isabel Carrio Montes
(I)
Maite Cia Lecumberri
(M)
Rosa Del Castillo Monsalvo
(R)
Elvira Diez Alvarez
(E)
César Antonio Egües Dubuc
(CA)
Maria Victoria Egurbide Arberas
(MV)
Patricia Fanlo Mateo
(P)
Maria Del Carmen Freire Dapena
(MDC)
Mercedes Freire González
(M)
Ángel García Aparicio
(Á)
Francisco José García Hernández
(FJ)
José Gómez de Salazar
(J)
José Antonio González Nieto
(JA)
Jenaro Graña Gil
(J)
Alfredo Guillén-Del-Castillo
(A)
José Izquierdo Hidalgo
(J)
Toni Juan Mas
(T)
Maria Cruz Laiño Piñeiro
(MC)
Francisco Javier López Longo
(FJ)
Lilian Maria López Núñez
(LM)
Adela Marín Ballvé
(A)
Carlos Marras Fernandez-Cid
(C)
Roberto Miguelez
(R)
Miguel Ángel Moran Rodriguez
(MÁ)
Juan Moreno Morales
(J)
Rosa Maria Morlà
(RM)
Soledad Ojeda Bruno
(S)
Alejandro Olivé Marqués
(A)
Enrique Ornilla Laraundogoitia
(E)
Noberto Ortego
(N)
Vera Ortiz Santamaria
(V)
Mercedes Pilar Pérez Conesa
(MP)
Trinidad Pérez Sandoval
(T)
Ana Pros Simon
(A)
Beatriz Rodríguez Lozano
(B)
Amalia Rueda Cid
(A)
Luis Sáez Comet
(L)
Juan Salvatierra Osorio
(J)
Alejandro Sanmartín López
(A)
Gregorio Santos Soler
(G)
Mónica Sarmiento Guevara
(M)
José Antonio Todolí Parra
(JA)
Carmelo Tornero Ramos
(C)
Juan Tovar Beltrán
(J)
Julia Maria Uceda Montañez
(JM)
Esther Vicente Rabaneda
(E)
Neus Valveny
(N)
Nerea Gallastegui
(N)
Références
Arthritis Care Res (Hoboken). 2011 Feb;63(2):277-85
pubmed: 20824802
Arthritis Rheum. 2007 Feb 15;57(1):94-102
pubmed: 17266096
Int J Rheumatol. 2010;2010:
pubmed: 20862342
Arthritis Rheum. 2002 Sep;46(9):2410-20
pubmed: 12355489
Arthritis Rheum. 2005 Apr 15;53(2):256-62
pubmed: 15818719
J Rheumatol. 2010 Nov;37(11):2307-12
pubmed: 20843907
Clin Exp Rheumatol. 2014 Nov-Dec;32(6 Suppl 86):S-15-20
pubmed: 24850211
Ann Rheum Dis. 2008 Jan;67(1):120-3
pubmed: 17660220
J Rheumatol. 2014 Jul;41(7):1317-23
pubmed: 24931950
Osteoarthritis Cartilage. 2001 Aug;9(6):570-7
pubmed: 11520171
Arthritis Rheum. 2004 Dec;50(12):3985-93
pubmed: 15593188
Rheumatology (Oxford). 2012 Feb;51(2):297-304
pubmed: 21972420
Ann Rheum Dis. 2010 Jan;69(1):214-7
pubmed: 19221115
J Rheumatol. 1988 Feb;15(2):202-5
pubmed: 3361530
Rheumatology (Oxford). 2006 Oct;45(10):1298-302
pubmed: 16754629
JAMA. 2013 Nov 27;310(20):2191-4
pubmed: 24141714
Pharmacoeconomics. 1993 Nov;4(5):353-65
pubmed: 10146874
Rheumatology (Oxford). 2012 Jul;51(7):1304-14
pubmed: 22427412
Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii19-24
pubmed: 19487218
Rheum Dis Clin North Am. 2003 May;29(2):275-91, vi
pubmed: 12841295