42936 pathogens from Canadian hospitals: 10 years of results (2007-16) from the CANWARD surveillance study.
Adolescent
Adult
Aged
Anti-Bacterial Agents
/ pharmacology
Canada
/ epidemiology
Drug Resistance, Bacterial
Epidemiological Monitoring
Escherichia coli
/ drug effects
Escherichia coli Infections
/ epidemiology
Female
Hospitals
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Pseudomonas Infections
/ epidemiology
Pseudomonas aeruginosa
/ drug effects
Staphylococcal Infections
/ epidemiology
Staphylococcus aureus
/ drug effects
Young Adult
Journal
The Journal of antimicrobial chemotherapy
ISSN: 1460-2091
Titre abrégé: J Antimicrob Chemother
Pays: England
ID NLM: 7513617
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
entrez:
11
9
2019
pubmed:
11
9
2019
medline:
28
7
2020
Statut:
ppublish
Résumé
The CANWARD surveillance study was established in 2007 to annually assess the in vitro susceptibilities of a variety of antimicrobial agents against bacterial pathogens isolated from patients receiving care in Canadian hospitals. 42 936 pathogens were received and CLSI broth microdilution testing was performed on 37 355 bacterial isolates. Limited patient demographic data submitted with each isolate were collated and analysed. Of the isolates tested, 43.5%, 33.1%, 13.2% and 10.2% were from blood, respiratory, urine and wound specimens, respectively; 29.9%, 24.8%, 19.0%, 18.1% and 8.2% of isolates were from patients in medical wards, emergency rooms, ICUs, hospital clinics and surgical wards. Patient demographics associated with the isolates were: 54.6% male/45.4% female; 13.1% patients aged ≤17 years, 44.3% 18-64 years and 42.7% ≥65 years. The three most common pathogens were Staphylococcus aureus (21.2%, both methicillin-susceptible and MRSA), Escherichia coli (19.6%) and Pseudomonas aeruginosa (9.0%). E. coli were most susceptible to meropenem and tigecycline (99.9%), ertapenem and colistin (99.8%), amikacin (99.7%) and ceftolozane/tazobactam and plazomicin (99.6%). Twenty-three percent of S. aureus were MRSA. MRSA were most susceptible to ceftobiprole, linezolid and telavancin (100%), daptomycin (99.9%), vancomycin (99.8%) and tigecycline (99.2%). P. aeruginosa were most susceptible to ceftolozane/tazobactam (98.3%) and colistin (95.0%). The CANWARD surveillance study has provided 10 years of reference antimicrobial susceptibility testing data on pathogens commonly causing infections in patients attending Canadian hospitals.
Identifiants
pubmed: 31505641
pii: 5553077
doi: 10.1093/jac/dkz283
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
iv5-iv21Investigateurs
George G Zhanel
(GG)
Daryl J Hoban
(DJ)
Heather J Adam
(HJ)
Melanie R Baxter
(MR)
Kimberly A Nichol
(KA)
Philippe R S Lagacé-Wiens
(PRS)
Andrew Walkty
(A)
James A Karlowsky
(JA)
J Blondeau
(J)
R Slinger
(R)
R Davidson
(R)
G Zhanel
(G)
D Hoban
(D)
J Delport
(J)
C Ellis
(C)
M Laverdière
(M)
V Loo
(V)
S Poutanen
(S)
J Fuller
(J)
D Roscoe
(D)
M Desjardins
(M)
L Matukas
(L)
M Goyette
(M)
C Lee
(C)
A Carignan
(A)
M Bergevin
(M)
R Pelletier
(R)
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.