Carbon fibers modified with polypyrrole for headspace solid phase microextraction of trace amounts of 2-pentyl furan from breath samples.
Adolescent
Adsorption
Adult
Biomarkers
/ analysis
Breath Tests
/ methods
Carbon Fiber
/ chemistry
Female
Furans
/ analysis
Humans
Limit of Detection
Male
Nitrogen
/ chemistry
Polymers
/ chemistry
Pyrroles
/ chemistry
Reproducibility of Results
Solid Phase Microextraction
/ methods
Temperature
Young Adult
2-Pentylfuran
Biomarkers
Carbon fibers
Headspace solid-phase microextraction
Journal
Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488
Informations de publication
Date de publication:
04 Jan 2020
04 Jan 2020
Historique:
received:
22
04
2019
revised:
27
08
2019
accepted:
29
08
2019
pubmed:
11
9
2019
medline:
7
3
2020
entrez:
11
9
2019
Statut:
ppublish
Résumé
This study introduces micrometric carbon strands as a suitable fiber for headspace solid phase microextraction. Compared to previous supports, carbon fibers have mechanical flexibility, wide thermal expansion, and a large surface area, which is an important factor in headspace solid phase microextraction. The electrophoretic technique was applied to modify the surface of stainless steel and carbon fibers with polypyrrole. Modified carbon fibers were used for extraction of 2-pentylfuran (2-PF) as a model analyte from patients' breath and coffee samples. 2-PF belongs to the furan family, which was suggested as a biomarker for Aspergillus fumigatus and was classified as a possible carcinogen. 2-PF can be found in many heat-processed foods and drinks. The separation and detection of the analyte was performed by gas chromatography coupled to mass spectrometry. The effective factors in the extraction performance of the analyte by carbon fiber supports were investigated and optimized. Under optimized extraction conditions (temperature, 20 °C; time, 15 min; desorption temperature, 200 °C; desorption time, 2 min; salt concentration, 10% w/v; and stirring rate, 700 rpm), the limit of detection was calculated as 0.05 ng mL
Identifiants
pubmed: 31500883
pii: S0021-9673(19)30883-0
doi: 10.1016/j.chroma.2019.460497
pii:
doi:
Substances chimiques
Biomarkers
0
Carbon Fiber
0
Furans
0
Polymers
0
Pyrroles
0
polypyrrole
30604-81-0
2-pentylfuran
6I0QAJ1JZQ
Nitrogen
N762921K75
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
460497Informations de copyright
Copyright © 2019. Published by Elsevier B.V.