Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from
Animals
Helminth Proteins
/ antagonists & inhibitors
Humans
Kinetics
Larva
/ drug effects
Lysine
/ chemistry
Niacinamide
/ chemistry
Oxadiazoles
/ chemistry
Peptides
/ chemistry
Pyrimidines
/ chemistry
Schistosoma mansoni
/ growth & development
Schistosomiasis
/ drug therapy
Sirtuin 2
/ antagonists & inhibitors
Structure-Activity Relationship
Substrate Specificity
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
10 10 2019
10 10 2019
Historique:
pubmed:
10
9
2019
medline:
17
6
2020
entrez:
10
9
2019
Statut:
ppublish
Résumé
The only drug currently available for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary and urgent. To this end, the targeting of
Identifiants
pubmed: 31496251
doi: 10.1021/acs.jmedchem.9b00638
doi:
Substances chimiques
Helminth Proteins
0
Oxadiazoles
0
Peptides
0
Pyrimidines
0
Niacinamide
25X51I8RD4
Sirtuin 2
EC 3.5.1.-
Lysine
K3Z4F929H6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM