Soluble CD14 in Breast Milk and Its Relation to Atopic Manifestations in Early Infancy.
allergen sensitization
atopic dermatitis
breast milk
soluble CD14
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
05 Sep 2019
05 Sep 2019
Historique:
received:
15
07
2019
revised:
29
08
2019
accepted:
30
08
2019
entrez:
8
9
2019
pubmed:
8
9
2019
medline:
25
2
2020
Statut:
epublish
Résumé
Soluble CD14 (sCD14) is one of the immunomodulatory factors in breast milk (BM). Although it may be involved in the prevention of atopic symptoms and sensitization to both food and inhalant allergens, conflicting evidence exists concerning its protective effects. In this study, we investigated the relationship between sCD14 in colostrum and 1-month BM, and the development of atopic dermatitis (AD) and sensitization to food and aeroallergens at 9 months of age in infants who were exclusively or almost exclusively breastfed up to 4 months of age. BM samples were collected from lactating mothers who participated in a 2 × 2 factorial, randomized, nontreatment controlled trial study set in Tokyo, which looked at the efficacy of emollients and synbiotics in preventing AD and food allergy in children during the first year of life. A total of 258 colostrum samples and 269 1-month BM samples were analyzed. We found that one-month BM sCD14 levels in the AD group were significantly lower than in the non-AD group. Levels of sCD14 in 1-month BM were not related to allergen sensitization in the overall analysis, but egg white sensitization correlated inversely with 1-month BM sCD14 in infants without AD. The results suggest that sCD14 in BM may be involved in atopic manifestations in early infancy.
Identifiants
pubmed: 31492016
pii: nu11092118
doi: 10.3390/nu11092118
pmc: PMC6770418
pii:
doi:
Substances chimiques
CD14 protein, human
0
Lipopolysaccharide Receptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Agency for Medical Research and Development
ID : J17JK00057 and J17JK00058
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