Counterfeit and Substandard Test of the Antimalarial Tablet Riamet
API
DFT calculations
PLSR
Raman spectroscopy
analytical spectroscopy
antimalarial tablets
artemether
chemometrics
counterfeit and substandard pharmaceuticals
hyperspectral imaging
lumefantrine
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
05 Sep 2019
05 Sep 2019
Historique:
received:
21
07
2019
revised:
31
08
2019
accepted:
02
09
2019
entrez:
8
9
2019
pubmed:
8
9
2019
medline:
28
1
2020
Statut:
epublish
Résumé
The fight against counterfeit pharmaceuticals is a global issue of utmost importance, as failed medication results in millions of deaths every year. Particularly affected are antimalarial tablets. A very important issue is the identification of substandard tablets that do not contain the nominal amounts of the active pharmaceutical ingredient (API), and the differentiation between genuine products and products without any active ingredient or with a false active ingredient. This work presents a novel approach based on fiber-array based Raman hyperspectral imaging to qualify and quantify the antimalarial APIs lumefantrine and artemether directly and non-invasively in a tablet in a time-efficient way. The investigations were carried out with the antimalarial tablet Riamet
Identifiants
pubmed: 31491881
pii: molecules24183229
doi: 10.3390/molecules24183229
pmc: PMC6767462
pii:
doi:
Substances chimiques
Antimalarials
0
Counterfeit Drugs
0
Tablets
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : federal state of Thuringia
ID : FKZ: 2015 FE 9012
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