Midpregnancy testing for soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF): An inter-assay comparison of three automated immunoassay platforms.

Biomarkers / blood Female Humans Immunoassay / instrumentation Placenta Growth Factor / blood Pregnancy Vascular Endothelial Growth Factor Receptor-1 / blood

Journal

Placenta
ISSN: 1532-3102
Titre abrégé: Placenta
Pays: Netherlands
ID NLM: 8006349

Informations de publication

Date de publication:
10 2019
Historique:
received: 18 02 2019
revised: 10 08 2019
accepted: 14 08 2019
pubmed: 7 9 2019
medline: 25 8 2020
entrez: 7 9 2019
Statut: ppublish

Résumé

We performed an inter-assay comparison among three immunoassay platforms for midpregnancy testing of sFlt-1, PlGF and the sFlt-1/PlGF ratio, which are established markers for pre-eclampsia. Maternal blood was collected 19-22 weeks' gestation. Raw data values were converted to multiples of the median (MoM). PlGF and sFlt-1 values among platforms were highly correlated (p < 0.001). There was significant variation in raw data values for PlGF and sFlt-1 among platforms, eliminated following conversion to MoM. When directly comparing raw data values among platforms, platform-specific reference ranges values should be used. MoM values were equivalent among platforms, allowing direct inter-assay result comparison.

Identifiants

DOI: 10.1016/j.placenta.2019.08.083 PMID: 31491692
pubmed: 31491692
pii: S0143-4004(19)30628-9
doi: 10.1016/j.placenta.2019.08.083
pii:
doi:

Substances chimiques

Biomarkers 0
Placenta Growth Factor 144589-93-5
FLT1 protein, human EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-1 EC 2.7.10.1

Types de publication

Comparative Study Evaluation Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11-14

Informations de copyright

Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.

Auteurs

Carin Black (C)

Pregnancy Research Centre, Department of Maternal-Fetal Medicine, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia; The University of Melbourne, Department of Obstetrics and Gynaecology, The Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia. Electronic address: carinblack@gmail.com.

Ahmed Al-Amin (A)

Department of Obstetrics and Gynaecology, Monash University, Wellington Rd, Clayton, Victoria, 3800, Australia; Pauline Gandel Imaging Centre, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia.

Daniel Lorber Rolnik (DL)

Perinatal Services, Monash Medical Centre, 246 Clayton Rd, Clayton, Victoria, 3168, Australia; Department of Obstetrics and Gynaecology, Monash University, Wellington Rd, Clayton, Victoria, 3800, Australia.

Stefan C Kane (SC)

Pregnancy Research Centre, Department of Maternal-Fetal Medicine, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia; The University of Melbourne, Department of Obstetrics and Gynaecology, The Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia; Pauline Gandel Imaging Centre, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia.

Caroline Stolarek (C)

Pregnancy Research Centre, Department of Maternal-Fetal Medicine, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia.

Adrienne White (A)

Pregnancy Research Centre, Department of Maternal-Fetal Medicine, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia.

Fabricio da Silva Costa (F)

Department of Gynecology and Obstetrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Perinatal Services, Monash Medical Centre, 246 Clayton Rd, Clayton, Victoria, 3168, Australia.

Shaun Brennecke (S)

Pregnancy Research Centre, Department of Maternal-Fetal Medicine, Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia; The University of Melbourne, Department of Obstetrics and Gynaecology, The Royal Women's Hospital, 20 Flemington Rd, Parkville, Victoria, 3052, Australia.

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Classifications MeSH

Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Midpregnancy testing for soluble fms-like...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Midpregnancy testing for soluble fms-like...
Recherchemedicale.com › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Midpregnancy testing for soluble fms-like...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines de la grossesse › Facteur de croissance placentaire › Midpregnancy testing for soluble fms-like...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Midpregnancy testing for soluble fms-like...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance endothéliale vasculaire › Récepteur-1 au facteur croissance endothéliale vasculaire › Midpregnancy testing for soluble fms-like...