Maternal age at menarche and offspring body mass index in childhood.
Body mass index
Early menarche
Intergenerational study
Journal
BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804
Informations de publication
Date de publication:
04 09 2019
04 09 2019
Historique:
received:
03
09
2018
accepted:
02
08
2019
entrez:
6
9
2019
pubmed:
6
9
2019
medline:
15
12
2020
Statut:
epublish
Résumé
Earlier age of menarche has been associated with an increased risk of chronic diseases during adulthood, but whether early menarche has intergenerational effect is not clear. In this population-based cross-sectional study, we recruited children from 26 primary schools using cluster random probability sampling in Shanghai, China, in 2014. We used multiple linear regression models to estimate the adjusted associations of maternal age of menarche (MAM) with offspring body mass index (BMI). We also used the mediation analysis to examine the contribution of maternal BMI and gestational diabetes to offspring BMI. A total of 17,571 children aged 6-13 years were enrolled, of whom 16,373 had their weight and height measured. Earlier MAM was associated with higher child BMI in boys (- 0.05 z-score per year older MAM, 95% CI - 0.08 to - 0.02) and in girls (- 0.05 z-score per year older MAM, 95% CI - 0.07 to - 0.02). Maternal BMI positively mediated the association of MAM with offspring BMI in both sexes, with mediation effects of 37.7 and 19.4% for boys and girls, respectively. Early maternal menarche was associated with greater offspring BMI. This study provides evidence for the intergenerational effect in the development of BMI in offspring.
Sections du résumé
BACKGROUND
Earlier age of menarche has been associated with an increased risk of chronic diseases during adulthood, but whether early menarche has intergenerational effect is not clear.
METHODS
In this population-based cross-sectional study, we recruited children from 26 primary schools using cluster random probability sampling in Shanghai, China, in 2014. We used multiple linear regression models to estimate the adjusted associations of maternal age of menarche (MAM) with offspring body mass index (BMI). We also used the mediation analysis to examine the contribution of maternal BMI and gestational diabetes to offspring BMI.
RESULTS
A total of 17,571 children aged 6-13 years were enrolled, of whom 16,373 had their weight and height measured. Earlier MAM was associated with higher child BMI in boys (- 0.05 z-score per year older MAM, 95% CI - 0.08 to - 0.02) and in girls (- 0.05 z-score per year older MAM, 95% CI - 0.07 to - 0.02). Maternal BMI positively mediated the association of MAM with offspring BMI in both sexes, with mediation effects of 37.7 and 19.4% for boys and girls, respectively.
CONCLUSION
Early maternal menarche was associated with greater offspring BMI. This study provides evidence for the intergenerational effect in the development of BMI in offspring.
Identifiants
pubmed: 31484496
doi: 10.1186/s12887-019-1659-4
pii: 10.1186/s12887-019-1659-4
pmc: PMC6724332
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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