Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection.
Animals
CD4-Positive T-Lymphocytes
/ microbiology
Coinfection
/ microbiology
Homeostasis
Latent Tuberculosis
/ complications
Lentivirus
Lymphocyte Depletion
Macaca mulatta
Mutation
Mycobacterium tuberculosis
Phenotype
Simian Acquired Immunodeficiency Syndrome
/ complications
Simian Immunodeficiency Virus
AIDS/HIV
Infectious disease
T cells
Tuberculosis
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
02 12 2019
02 12 2019
Historique:
received:
19
02
2019
accepted:
29
08
2019
pubmed:
4
9
2019
medline:
23
6
2020
entrez:
4
9
2019
Statut:
ppublish
Résumé
HIV is a major driver of tuberculosis (TB) reactivation. Depletion of CD4+ T cells is assumed to be the basis behind TB reactivation in individuals with latent tuberculosis infection (LTBI) coinfected with HIV. Nonhuman primates (NHPs) coinfected with a mutant simian immunodeficiency virus (SIVΔGY) that does not cause depletion of tissue CD4+ T cells during infection failed to reactivate TB. To investigate the contribution of CD4+ T cell depletion relative to other mechanisms of SIV-induced reactivation of LTBI, we used CD4R1 antibody to deplete CD4+ T cells in animals with LTBI without lentiviral infection. The mere depletion of CD4+ T cells during LTBI was insufficient in generating reactivation of LTBI. Instead, direct cytopathic effects of SIV resulting in chronic immune activation, along with the altered effector T cell phenotypes and dysregulated T cell homeostasis, were likely mediators of reactivation of LTBI. These results revealed important implications for TB control in HIV-coinfected individuals.
Identifiants
pubmed: 31479428
pii: 125810
doi: 10.1172/JCI125810
pmc: PMC6877319
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5254-5260Subventions
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111914
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI123047
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI111943
Pays : United States
Organisme : NIH HHS
ID : P51 OD011104
Pays : United States
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