Cholesterol-conjugated stapled peptides inhibit Ebola and Marburg viruses in vitro and in vivo.

Amino Acid Sequence Animals Antiviral Agents / chemistry Cell Line Cholesterol / chemistry Disease Models, Animal Ebolavirus / drug effects Hemorrhagic Fever, Ebola / virology Marburg Virus Disease / virology Marburgvirus / drug effects Mice Microbial Sensitivity Tests Models, Molecular Peptides / chemistry Protein Conformation Structure-Activity Relationship
Cholesterol Ebola virus Peptides Rodents Therapeutic

Journal

Antiviral research
ISSN: 1872-9096
Titre abrégé: Antiviral Res
Pays: Netherlands
ID NLM: 8109699

Informations de publication

Date de publication:
11 2019
Historique:
received: 09 06 2019
revised: 22 08 2019
accepted: 25 08 2019
pubmed: 2 9 2019
medline: 9 7 2020
entrez: 2 9 2019
Statut: ppublish

Résumé

Filoviridae currently includes five official and one proposed genera. Genus Ebolavirus includes five established and one proposed ebolavirus species for Bombali virus (BOMV), Bundibugyo virus (BDBV), Ebola virus (EBOV), Reston virus (RESTV), Sudan virus (SUDV) and Taï Forest virus (TAFV), and genus Marburgvirus includes a single species for Marburg virus (MARV) and Ravn virus (RAVV). Ebola virus (EBOV) has emerged as a significant public health concern since the 2013-2016 Ebola Virus Disease outbreak in Western Africa. Currently, there are no therapeutics approved and the need for Ebola-specific therapeutics remains a gap. In search for anti-Ebola therapies we tested the idea of using inhibitory properties of peptides corresponding to the C-terminal heptad-repeat (HR2) domains of class I fusion proteins against EBOV infection. The fusion protein GP

Identifiants

DOI: 10.1016/j.antiviral.2019.104592 PMID: 31473342
pubmed: 31473342
pii: S0166-3542(19)30299-2
doi: 10.1016/j.antiviral.2019.104592
pii:
doi:

Substances chimiques

Antiviral Agents 0
Peptides 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

104592

Informations de copyright

Published by Elsevier B.V.

Auteurs

Antonello Pessi (A)

PeptiPharma, Rome, Italy.

Sandra L Bixler (SL)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA.

Veronica Soloveva (V)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA.

Sheli Radoshitzky (S)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA.

Cary Retterer (C)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Tara Kenny (T)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Rouzbeh Zamani (R)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Glenn Gomba (G)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Dima Gharabeih (D)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Jay Wells (J)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Kelly S Wetzel (KS)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Travis K Warren (TK)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA.

Ginger Donnelly (G)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Sean A Van Tongeren (SA)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Jesse Steffens (J)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA.

Allen J Duplantier (AJ)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA.

Christopher D Kane (CD)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA; Therapeutic Development Center, USAMRIID, Frederick, MD, 21702, USA. Electronic address: christopher.d.kane.civ@mail.mil.

Pascale Vicat (P)

Sanofi, Paris, France.

Valerie Couturier (V)

Sanofi, Paris, France.

Kent E Kester (KE)

Sanofi Pasteur, Swiftwater, PA, USA.

John Shiver (J)

Sanofi Pasteur, Swiftwater, PA, USA.

Kara Carter (K)

Sanofi, Cambridge, MA, USA.

Sina Bavari (S)

United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Frederick, MD, 21702, USA. Electronic address: sina.bavari.civ@mail.mil.

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Classifications MeSH

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