Network Analysis of a Membrane-Enriched Brain Proteome across Stages of Alzheimer's Disease.
biomarkers
preclinical
proteomics
synapse
vesicles
Journal
Proteomes
ISSN: 2227-7382
Titre abrégé: Proteomes
Pays: Switzerland
ID NLM: 101621966
Informations de publication
Date de publication:
27 Aug 2019
27 Aug 2019
Historique:
received:
26
06
2019
revised:
20
08
2019
accepted:
22
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
30
8
2019
Statut:
epublish
Résumé
Previous systems-based proteomic approaches have characterized alterations in protein co-expression networks of unfractionated asymptomatic (AsymAD) and symptomatic Alzheimer's disease (AD) brains. However, it remains unclear how sample fractionation and sub-proteomic analysis influences the organization of these protein networks and their relationship to clinicopathological traits of disease. In this proof-of-concept study, we performed a systems-based sub-proteomic analysis of membrane-enriched post-mortem brain samples from pathology-free control, AsymAD, and AD brains (
Identifiants
pubmed: 31461916
pii: proteomes7030030
doi: 10.3390/proteomes7030030
pmc: PMC6789842
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIA NIH HHS
ID : R01AG053960
Pays : United States
Organisme : National Instiute on Aging
ID : R01AG057911
Organisme : NIA NIH HHS
ID : R01AG061800
Pays : United States
Organisme : Accelerating Medicine Partnership for AD
ID : U01AG046161
Organisme : Emory Alzheimer's Disease Research Center
ID : P50AG025688
Organisme : NINDS Emory Neuroscience Core
ID : P30NS055077
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