Tungsten carbide nanoparticles show a broad spectrum virucidal activity against enveloped and nonenveloped model viruses using a guideline-standardized in vitro test.
broad spectrum
disinfectant
quantitative suspension test
tungsten carbide
virucidal activity
Journal
Letters in applied microbiology
ISSN: 1472-765X
Titre abrégé: Lett Appl Microbiol
Pays: England
ID NLM: 8510094
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
11
06
2019
revised:
15
08
2019
accepted:
15
08
2019
pubmed:
23
8
2019
medline:
20
11
2019
entrez:
23
8
2019
Statut:
ppublish
Résumé
Five tungsten carbide nanoparticle preparations (denoted WC1-WC5) were investigated for broad spectrum virucidal activity against four recommended model viruses. These are modified vaccinia virus Ankara (MVA), human adenovirus type 5 (HAdV-5), poliovirus type 1 (PV-1) and murine norovirus (MNV). All virucidal tests were performed two to five times using the quantitative suspension test, which is a highly standardized test method to evaluate the virucidal efficacy of disinfectants in accordance with the European norm EN 14476+A1 and the German DVV/RKI guidelines. Quantitative detection of viruses was conducted by endpoint titration and quantitative real-time PCR. Results showed that three of the five tested compounds (WC1-WC3) were able to reduce the infectivity of all model viruses by at least four log
Substances chimiques
Disinfectants
0
Tungsten Compounds
0
tungsten carbide
11130-73-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
302-309Informations de copyright
© 2019 The Society for Applied Microbiology.
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