Disproportionate Effect of Sub-Micron Topography on Osteoconductive Capability of Titanium.
acid-etching
bone integration
bone regeneration
dental implants
micro-rough
orthopedic implants
osseointegration
sub-micro-rough
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Aug 2019
18 Aug 2019
Historique:
received:
02
07
2019
revised:
16
08
2019
accepted:
17
08
2019
entrez:
21
8
2019
pubmed:
21
8
2019
medline:
10
1
2020
Statut:
epublish
Résumé
Titanium micro-scale topography offers excellent osteoconductivity and bone-implant integration. However, the biological effects of sub-micron topography are unknown. We compared osteoblastic phenotypes and in vivo bone and implant integration abilities between titanium surfaces with micro- (1-5 µm) and sub-micro-scale (0.1-0.5 µm) compartmental structures and machined titanium. The calculated average roughness was 12.5 ± 0.65, 123 ± 6.15, and 24 ± 1.2 nm for machined, micro-rough, and sub-micro-rough surfaces, respectively. In culture studies using bone marrow-derived osteoblasts, the micro-rough surface showed the lowest proliferation and fewest cells attaching during the initial stage. Calcium deposition and expression of osteoblastic genes were highest on the sub-micro-rough surface. The bone-implant integration in the Sprague-Dawley male rat femur model was the strongest on the micro-rough surface. Thus, the biological effects of titanium surfaces are not necessarily proportional to the degree of roughness in osteoblastic cultures or in vivo. Sub-micro-rough titanium ameliorates the disadvantage of micro-rough titanium by restoring cell attachment and proliferation. However, bone integration and the ability to retain cells are compromised due to its lower interfacial mechanical locking. This is the first report on sub-micron topography on a titanium surface promoting osteoblast function with minimal osseointegration.
Identifiants
pubmed: 31426563
pii: ijms20164027
doi: 10.3390/ijms20164027
pmc: PMC6720784
pii:
doi:
Substances chimiques
Titanium
D1JT611TNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Biomaterials. 1999 Jul;20(14):1293-301
pubmed: 10403047
J Dent Res. 2000 Nov;79(11):1857-63
pubmed: 11145355
Biomaterials. 2001 Jun;22(11):1241-51
pubmed: 11336296
J Biomed Mater Res. 2002 Apr;60(1):70-8
pubmed: 11835161
J Biomed Mater Res. 2002 Dec 5;62(3):350-8
pubmed: 12209920
Eur Cell Mater. 2003 Oct 24;6:22-7
pubmed: 14577052
Calcif Tissue Int. 1992 Nov;51(5):376-81
pubmed: 1458342
Biomaterials. 2005 Jan;26(3):285-95
pubmed: 15262470
J Biomed Mater Res A. 2005 Mar 1;72(3):296-305
pubmed: 15654712
J Bone Miner Res. 2005 Nov;20(11):2002-16
pubmed: 16234974
Dent Mater. 2007 Jul;23(7):844-54
pubmed: 16904738
J Biomed Mater Res A. 2008 Jan;84(1):108-16
pubmed: 17600332
Biomaterials. 2007 Dec;28(36):5418-25
pubmed: 17868850
Nat Mater. 2007 Dec;6(12):997-1003
pubmed: 17891143
Dent Mater J. 2008 May;27(3):415-21
pubmed: 18717170
Endocrinology. 1991 Jun;128(6):3144-51
pubmed: 1903700
Biomaterials. 2009 Feb;30(6):1015-25
pubmed: 19042016
Biomaterials. 2009 Mar;30(7):1273-80
pubmed: 19095298
Biomaterials. 2009 Jul;30(20):3390-6
pubmed: 19395022
Int J Oral Maxillofac Implants. 2009 May-Jun;24(3):419-31
pubmed: 19587863
Biomaterials. 2009 Oct;30(29):5319-29
pubmed: 19589591
J Dent Res. 2009 Sep;88(9):812-6
pubmed: 19767577
Biochem Biophys Res Commun. 1991 Jan 15;174(1):96-101
pubmed: 1989624
Dent Mater. 2010 Apr;26(4):275-87
pubmed: 20006380
Biomaterials. 2010 Apr;31(10):2728-35
pubmed: 20053436
Biochem Biophys Res Commun. 1990 Jan 30;166(2):750-6
pubmed: 2154218
Endocrinology. 1990 Apr;126(4):2088-94
pubmed: 2156680
Endocrinology. 1990 Aug;127(2):807-14
pubmed: 2164921
Endocrinology. 1990 Feb;126(2):1076-9
pubmed: 2298153
J Biomed Mater Res A. 2014 Apr;102(4):1092-101
pubmed: 23630099
J Biomater Appl. 2014 Apr;28(8):1200-12
pubmed: 23985537
Acta Biomater. 2014 Aug;10(8):3363-71
pubmed: 24721613
J Biomed Mater Res A. 2015 Feb;103(2):564-73
pubmed: 24733736
Implant Dent. 2015 Feb;24(1):62-9
pubmed: 25621551
J Hand Surg Am. 2015 Aug;40(8):1703-10, 1710.e1-4
pubmed: 26143030
Int J Oral Maxillofac Implants. 2015 Jul-Aug;30(4):868-79
pubmed: 26252039
Biomed Res Int. 2015;2015:791725
pubmed: 26436097
J Biomater Appl. 2016 Mar;30(8):1242-50
pubmed: 26656313
Adv Dent Res. 2016 Mar;28(1):10-7
pubmed: 26927483
Implant Dent. 2016 Dec;25(6):744-750
pubmed: 27513161
Otol Neurotol. 2016 Oct;37(9):1291-9
pubmed: 27579835
Mater Sci Eng C Mater Biol Appl. 2016 Dec 1;69:1429-41
pubmed: 27612843
Biomark Res. 2016 Dec 14;4:24
pubmed: 27999672
Periodontol 2000. 2017 Feb;73(1):22-40
pubmed: 28000277
J Biomater Appl. 2017 Feb;31(7):1049-1061
pubmed: 28056602
J Prosthet Dent. 2017 Sep;118(3):357-362
pubmed: 28222880
J Craniomaxillofac Surg. 2017 May;45(5):704-709
pubmed: 28318918
J Med Eng. 2017;2017:3069351
pubmed: 28717644
Tissue Eng Part A. 2017 Dec;23(23-24):1479-1489
pubmed: 28793839
Int J Mol Sci. 2017 Sep 05;18(9):null
pubmed: 28872625
J Clin Diagn Res. 2017 Jul;11(7):MD03-MD05
pubmed: 28892943
Biochem Biophys Res Commun. 1989 Mar 31;159(3):1206-12
pubmed: 2930558
Int J Nanomedicine. 2018 Jun 08;13:3381-3395
pubmed: 29922058
J Nat Med. 2019 Jan;73(1):104-113
pubmed: 30218208
Biomaterials. 2019 Feb;192:62-74
pubmed: 30428407
Cell Tissue Res. 1988 Nov;254(2):317-30
pubmed: 3197089
Biochem Biophys Res Commun. 1994 Dec 15;205(2):1187-93
pubmed: 7802649
J Cell Biochem. 1994 Jul;55(3):310-20
pubmed: 7962162