Glucocorticoids and Catecholamines Affect in Vitro Functionality of Porcine Blood Immune Cells.
adrenaline
catecholamines
cortisol
cytokines
immune system
lymphocytes
noradrenaline
pig
stress
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
12 Aug 2019
12 Aug 2019
Historique:
received:
01
07
2019
revised:
07
08
2019
accepted:
09
08
2019
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
15
8
2019
Statut:
epublish
Résumé
Stress hormones exert important modulating influences on the functionality of immune cells. Despite its major role as a livestock animal and its increasing use as an animal model, knowledge about this relationship in the domestic pig is rare. This study therefore aimed to characterize the effect of glucocorticoids and catecholamines on the proliferation and cytokine production of porcine peripheral blood mononuclear cells (PBMC). Blood was obtained from donor pigs equipped with indwelling catheters to exclude stress hormone exposition before in vitro testing. PBMC were stimulated in the presence of cortisol, adrenaline or noradrenaline at concentrations resembling low to high stress conditions. Proliferation was determined via
Identifiants
pubmed: 31408932
pii: ani9080545
doi: 10.3390/ani9080545
pmc: PMC6720833
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : STE 633/10-1
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