Pyrrolomycins Are Potent Natural Protonophores.
antibiotic
antibiotic resistance
mechanisms of action
protonophore
pyrrolomycin
uncoupler
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
18
07
2019
accepted:
31
07
2019
pubmed:
14
8
2019
medline:
4
8
2020
entrez:
14
8
2019
Statut:
epublish
Résumé
The escalating burden of antibiotic drug resistance necessitates research into novel classes of antibiotics and their mechanism of action. Pyrrolomycins are a family of potent natural product antibiotics with nanomolar activity against Gram-positive bacteria, yet with an elusive mechanism of action. In this work, we dissect the apparent Gram-positive specific activity of pyrrolomycins and show that Gram-negative bacteria are equally sensitive to pyrrolomycins when drug efflux transporters are removed and that albumin in medium plays a large role in pyrrolomycin activity. The selection of resistant mutants allowed for the characterization and validation of a number of mechanisms of resistance to pyrrolomycins in both
Identifiants
pubmed: 31405863
pii: AAC.01450-19
doi: 10.1128/AAC.01450-19
pmc: PMC6761498
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Pyrroles
0
pyrrolomycin C
81910-06-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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