Potential hepatoxicity risk of the shell of Herpetospermum caudigerum Wall in rats based on
Animals
Biomarkers
/ blood
Chemical and Drug Induced Liver Injury
/ diagnosis
Cucurbitaceae
/ toxicity
Disease Models, Animal
Ethanol
/ chemistry
Humans
Liver Function Tests
/ methods
Male
Medicine, Tibetan Traditional
/ adverse effects
Metabolomics
/ methods
Plant Extracts
/ isolation & purification
Proton Magnetic Resonance Spectroscopy
Rats
Herpetospermum caudigerum Wall shell
Liver damage
Metabolomics
NMR
OSC- PLSDA
Journal
Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336
Informations de publication
Date de publication:
30 Nov 2019
30 Nov 2019
Historique:
received:
22
05
2019
revised:
09
07
2019
accepted:
31
07
2019
pubmed:
9
8
2019
medline:
11
3
2020
entrez:
9
8
2019
Statut:
ppublish
Résumé
The Herpetospermum caudigerum Wall (HCW) is a traditional Tibetan medicine and is widely used in clinical practice. However, the shell of the HCW (SHCW) has rarely been studied, and some researchers have suggested that the SHCW may be toxic. Therefore, in this study, SHCW was administered to rats at two doses (0.1 and 0.33 g/kg) once a day for 21 days. The hepatic stimuli induced by SHCW in rats were investigated for the first time by
Identifiants
pubmed: 31394304
pii: S0731-7085(19)31265-8
doi: 10.1016/j.jpba.2019.112800
pii:
doi:
Substances chimiques
Biomarkers
0
Plant Extracts
0
Ethanol
3K9958V90M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112800Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.